Synthesis and antimicrobial activity of some 2,5-disubstituted 1,3,4-oxadiazoles

被引：0

作者：

Honnalli, SS ^{[1
]}

Ronad, PM ^{[1
]}

Vijaybhasker, K ^{[1
]}

Hukkeri, VI ^{[1
]}

Kumar, R ^{[1
]}

机构：

[1] KLEs Coll Pharm, Dept Pharmaceut Chem, Vijayanagar 580031, Hubli, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2005年 / 11卷 / 06期

关键词：

oxadiazole; propionate;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Chloro aniline is condensed with methyl acrylate in presence of acetic acid to yield methyl-beta-(4-chloro methyl aniline)-propionate, which was further treated with hydrazine hydrate in presence of ethanol to obtain beta -alanine-N-(4-chloro methyl-phenyl) hydrazide, on cyclization with ethanolic potassium hydroxide and carbon disulphide gives 2-mercapto-5-(4-chloro methyl-anilino ethyl)-1,3,4-oxadiazole (1-4). These oxadiazoles on refluxing with Morpholine / Piperidine / Dimethylamine Diethylamine gave 2,5-disubstituted derivatives. Antimicrobial activity of these compounds was studied (5).

引用

页码：505 / 508

页数：4

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