Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

被引：20

作者：

Tachibana, Keisuke ^{[1
]}

Anzai, Naohiko ^{[2
]}

Ueda, Chihiro ^{[1
]}

Katayama, Tatsuya ^{[1
]}

Yamasaki, Daisuke ^{[1
,3
]}

Kirino, Takayoshi ^{[1
]}

Takahashi, Rika ^{[1
]}

Ishimoto, Kenji ^{[1
,4
]}

Komori, Hidenori ^{[5
]}

Tanaka, Toshiya ^{[6
]}

Hamakubo, Takao ^{[6
]}

Ueda, Yukihiko ^{[7
]}

Arai, Hiroyuki ^{[8
]}

Sakai, Juro ^{[6
]}

Kodama, Tatsuhiko ^{[6
]}

Doi, Takefumi ^{[1
,3
,4
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo 1818611, Japan

[3] Osaka Univ, Ctr Adv Med Engn & Informat, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Med, Suita, Osaka 5650871, Japan

[5] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan

[6] Univ Tokyo, Res Ctr Adv Sci & Technol, Lab Syst Biol & Med, Tokyo 1538904, Japan

[7] Hirakata Kohsai Hosp, Osaka 5730153, Japan

[8] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Hlth Chem, Tokyo 1130033, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 28期

关键词：

PPAR alpha; PDZK1; PPRE; Target gene;

D O I：

10.1016/j.febslet.2008.10.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPAR alpha) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARa and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARa regulates PDZK1 expression. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3884 / 3888

页数：5

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