Stereocontrolled transesterification for the synthesis of chiral phosphite triester backbone

被引：5

作者：

Mizuguchi, M

Makino, K

机构：

[1] KYOTO INST TECHNOL,DEPT POLYMER SCI & ENGN,SAKYO KU,KYOTO 606,JAPAN

[2] RATIONAL DRUG DESIGN LABS,MATSUKAWA,FUKUSHIMA 96012,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 1-3期

关键词：

D O I：

10.1080/07328319608002394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed stereocontrolled transesterification for the synthesis of chiral phosphite triester backbone under basic conditions. Substrate phosphite triesters with phenoxy derivative substituents as leaving groups were separated into individual stereoisomers and reacted with hydroxyl-containing compounds to form desired backbone.

引用

页码：407 / 417

页数：11

共 50 条

[41] THE NEW HIGH HINDERED CHIRAL CATALYST FOR STEREOCONTROLLED SYNTHESIS OF DIETHYLZINC TO BENZALDEHYDE
JIANG, YZ
LI, SJ
MI, AG
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 165 - ORGN
[42] USE OF 2-PHENYLSULFONYLETHYL AS A PHOSPHATE PROTECTING GROUP IN DNA-SYNTHESIS USING THE PHOSPHITE-TRIESTER APPROACH
BALGOBIN, N
CHATTOPADHYAYA, J
ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1985, 39 (10): : 883 - 888
[43] POLYMER SUPPORT OLIGONUCLEOTIDE SYNTHESIS .15. SYNTHESIS OF OLIGODEOXYNUCLEOTIDES ON CONTROLLED PORE GLASS (CPG) USING PHOSPHATE AND A NEW PHOSPHITE TRIESTER APPROACH
KOSTER, H
BIERNAT, J
MCMANUS, J
WOLTER, A
STUMPE, A
NARANG, CK
SINHA, ND
TETRAHEDRON, 1984, 40 (01) : 103 - 112
[44] Hydrolysis and intramolecular transesterification of 3′-thioinosine 3′-S-phosphorothiolate triester
Elzagheid, MI
Mäki, E
Kaukinen, U
Oivanen, M
Lönnberg, H
CHEMISTRY OF NUCLEIC ACID COMPONENTS, 1999, 2 : 1 - 5
[45] Synthesis of poly(alkylene phosphonate)s polymers via the transesterification of dimethyl phosphite with diols.
Bharara, PC
Byrd, H
Farmer, BS
Boroughs, DB
Gray, GM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U533 - U534
[46] SOLID-PHASE SYNTHESIS OF OLIGORIBONUCLEOTIDES USING O-NITROBENZYL PROTECTION OF 2'-HYDROXYL VIA A PHOSPHITE TRIESTER APPROACH
TANAKA, T
TAMATSUKURI, S
IKEHARA, M
NUCLEIC ACIDS RESEARCH, 1986, 14 (15) : 6265 - 6279
[47] APPLICATION OF THE PHOSPHORAMIDITE-PHOSPHITE TRIESTER APPROACH FOR THE SYNTHESIS OF COMBINATIONS BETWEEN OXYGENATED STEROLS AND NUCLEOSIDE ANALOGS LINKED BY PHOSPHODIESTER BONDS
JI, YH
BANNWARTH, W
LUU, B
TETRAHEDRON, 1990, 46 (02) : 487 - 502
[48] Synthesis of a novel chiral biphenyl diphosphine ligand with more chiral centers on the backbone.
Qui, LQ
Pai, CC
Zhou, ZY
Yeung, CH
Choi, MCK
Chan, ASC
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U201 - U201
[49] Synthesis of a side chain liquid crystalline polycarbonate with a chiral backbone
Sahin, Y. Muge Calik
Serhatli, I. Ersin
Menceloglu, Yusuf Z.
Journal of Applied Polymer Science, 2006, 102 (02): : 1915 - 1921
[50] SYNTHESIS AND AGGREGATION BEHAVIOR OF CHIRAL POSPHOLIPIDS WITH PANTOIC ACID BACKBONE
GRANZER, UH
STAATZ, I
ROTH, HJ
LIEBIGS ANNALEN DER CHEMIE, 1989, (01): : 59 - 67

← 1 2 3 4 5 →