Stereocontrolled transesterification for the synthesis of chiral phosphite triester backbone

被引：5
|
作者：
Mizuguchi, M
Makino, K
机构：
[1] KYOTO INST TECHNOL,DEPT POLYMER SCI & ENGN,SAKYO KU,KYOTO 606,JAPAN
[2] RATIONAL DRUG DESIGN LABS,MATSUKAWA,FUKUSHIMA 96012,JAPAN
来源：
NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 1-3期
关键词：
D O I：
10.1080/07328319608002394
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed stereocontrolled transesterification for the synthesis of chiral phosphite triester backbone under basic conditions. Substrate phosphite triesters with phenoxy derivative substituents as leaving groups were separated into individual stereoisomers and reacted with hydroxyl-containing compounds to form desired backbone.
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页码：407 / 417
页数：11
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