MLN8054, a selective inhibitor of Aurora A kinase: final results of a phase I clinical trial

被引：1
|
作者：
Cervantes, A. [1 ]
Macarulla, T. [2 ]
Rosello, S. [1 ]
Rodriguez-Braun, E. [1 ]
Baselga, J. [2 ]
Tabernero, J. [2 ]
Liu, H. [5 ]
Chakravarty, A. [3 ]
Bowman, D. [4 ]
Eton, O. [6 ]
机构：
[1] Hosp Clin Univ Valencia, Valencia, Spain
[2] Vall Hebron Univ Hosp, Barcelona, Spain
[3] Millennium Pharmaceut Inc, Canc Pharmacol, Cambridge, MA USA
[4] Millennium Pharmaceut Inc, Mol & Cellular Oncol, Cambridge, MA USA
[5] Millennium Pharmaceut Inc, Biostat, Cambridge, MA USA
[6] Millennium Pharmaceut Inc, Oncol Clin Res, Cambridge, MA USA
来源：
EJC SUPPLEMENTS | 2008年 / 6卷 / 12期
关键词：
D O I：
10.1016/S1359-6349(08)72213-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：90 / 90
页数：1
相关论文
共 50 条
  • [11] Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
    Manfredi, Mark G.
    Ecsedy, Jeffrey A.
    Meetze, Kristan A.
    Balani, Suresh K.
    Burenkova, Olga
    Chen, Wei
    Galvin, Katherine M.
    Hoar, Kara M.
    Huck, Jessica J.
    LeRoy, Patrick J.
    Ray, Emily T.
    Sells, Todd B.
    Stringer, Bradley
    Stroud, Stephen G.
    Vos, Tricia J.
    Weatherhead, Gabriel S.
    Wysong, Deborah R.
    Zhang, Mengkun
    Bolen, Joseph B.
    Claiborne, Christopher F.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (10) : 4106 - 4111
  • [12] Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the selective aurora A kinase (AAK) inhibitor MLN8054 in patients (pts) with advanced solid tumors
    Macarulla, T.
    Rodriguez-Braun, E.
    Tabernero, J.
    Rosello, S.
    Baselga, J.
    Lee, Y.
    Manfredi, M.
    Liu, H.
    Fingert, H.
    Cervantes, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [13] Preclinical PK/PD/Efficacy relationship of MLN8054, a small molecule Aurora A kinase inhibitor
    Huck, Jessica
    Chakravarty, Arijit
    Yu, Li
    Zhang, Mengkun
    Burke, Kristine
    Kim, Mi-Sook
    Stringer, Bradley
    Sells, Todd
    Claiborne, Christopher
    Manfred, Mark
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3589S - 3590S
  • [14] MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
    Sells, Todd B.
    Chau, Ryan
    Ecsedy, Jeffrey A.
    Gershman, Rachel E.
    Hoar, Kara
    Huck, Jessica
    Janowick, David A.
    Kadambi, Vivek J.
    LeRoy, Patrick J.
    Stirling, Matthew
    Stroud, Stephen G.
    Vos, Tricia J.
    Weatherhead, Gabriel S.
    Wysong, Deborah R.
    Zhang, Mengkun
    Balani, Suresh K.
    Bolen, Joseph B.
    Manfredi, Mark G.
    Claiborne, Christopher F.
    ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (06): : 630 - 634
  • [15] Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
    Chakravarty, Arijit
    Shinde, Vaishali
    Tabernero, Josep
    Cervantes, Andres
    Cohen, Roger B.
    Dees, E. Claire
    Burris, Howard
    Infante, Jeffrey R.
    Macarulla, Teresa
    Elez, Elena
    Andreu, Jordi
    Rodriguez-Braun, Edith
    Rosello, Susana
    von Mehren, Margaret
    Meropol, Neal J.
    Langer, Corey J.
    ONeil, Bert
    Bowman, Douglas
    Zhang, Mengkun
    Danaee, Hadi
    Faron-Yowe, Laura
    Gray, Gary
    Liu, Hua
    Pappas, Jodi
    Silverman, Lee
    Simpson, Chris
    Stringer, Bradley
    Tirrell, Stephen
    Veiby, Ole Petter
    Venkatakrishnan, Karthik
    Galvin, Katherine
    Manfredi, Mark
    Ecsedy, Jeffrey A.
    CANCER RESEARCH, 2011, 71 (03) : 675 - 685
  • [16] MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo
    Huck, Jessica J.
    Zhang, Mengkun
    McDonald, Alice
    Bowman, Doug
    Hoar, Kara M.
    Stringer, Bradley
    Ecsedy, Jeffery
    Manfredi, Mark G.
    Hyer, Marc L.
    MOLECULAR CANCER RESEARCH, 2010, 8 (03) : 373 - 384
  • [17] MLN8054, an Aurora A Kinase inhibitor, demonstrates potent anti-tumor activity in disseminated tumor models
    Zhang, M.
    Meetze, M.
    Huck, J.
    Silva, M.
    Sells, T.
    Claiborne, C.
    Manfredi, M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 113 - 113
  • [18] MLN8054, an inhibitor of Aurora A Kinase, induces senescence in human tumor cells both in vitro and in vivo.
    Hyer, Marc
    Huck, Jessica
    Chakravarty, Arijit
    Bowman, Doug
    Zhang, Menkun
    Ecsedy, Jeff
    McDonald, Alice
    Stringer, Bradley
    Manfredi, Mark
    CANCER RESEARCH, 2009, 69
  • [19] MLN8054, A SMALL MOLECULE INHIBITOR OF AURORA KINASE A, SENSITIZES ANDROGEN-RESISTANT PROSTATE CANCER TO RADIATION
    Moretti, Luigi
    Niermann, Kenneth
    Schleicher, Stephen
    Giacalone, Nicholas J.
    Varki, Vinod
    Kim, Kwang Woon
    Kopsombut, Prapaporn
    Jung, Dae Kwang
    Lu, Bo
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 80 (04): : 1189 - 1197
  • [20] MLN8054, A NOVEL INHIBITOR OF AURORA KINASE A SENSITIZES ANDROGEN-RESISTANT PROSTATE CANCER MODELS TO RADIATION
    Moretti, L.
    Niermann, K.
    Schleicher, S.
    Kim, K. W.
    Kopsombut, P.
    Jung, D. K.
    Lu, B.
    RADIOTHERAPY AND ONCOLOGY, 2011, 99 : S386 - S386
12345