Alternative lengthening of telomeres in normal mammalian somatic cells

被引：115
|
作者：
Neumann, Axel A. [1 ,2 ]
Watson, Catherine M. [2 ,3 ]
Noble, Jane R. [1 ]
Pickett, Hilda A. [1 ,2 ]
Tam, Patrick P. L. [2 ,3 ]
Reddel, Roger R. [1 ,2 ]
机构：
[1] Childrens Med Res Inst, Canc Res Unit, Westmead, NSW 2145, Australia
[2] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia
[3] Childrens Med Res Inst, Embryol Unit, Westmead, NSW 2145, Australia
来源：
GENES & DEVELOPMENT | 2013年 / 27卷 / 01期
基金：
英国医学研究理事会;
关键词：
ALT; recombination; telomeres; MOUSE; ELONGATION; MAINTENANCE; DYNAMICS; SEQUENCE; TUMORS; ASSAY; MICE; RNA; DNA;
D O I：
10.1101/gad.205062.112
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we generated a mouse strain containing a DNA tag in a single telomere. We found that the tagged telomere was copied by other telomeres in somatic tissues but not the germline. The tagged telomere was also copied by other telomeres when introgressed into CAST/EiJ mice, which have telomeres more similar in length to those of humans. We conclude that ALT activity occurs in normal mouse somatic tissues.
引用
收藏
页码：18 / 23
页数：6
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