Piperidinium-Based Deep Eutectic Solvents: Efficient and Sustainable Eco-Friendly Medium for One-Pot N-Heterocycles Synthesis

There is a significant use of different kinds of hazardous materials, solvents, and catalysts in laboratories and industries for the production of different useful products. All over the globe millions of pharmaceutical industries are working for production of different kinds of drugs/compounds, consequently there is a need to limit (or replace) the use of such materials so as to reduce the environmental and health issues. In this regard, one of the strategies is to replace traditional obnoxious solvents and chemicals with different kinds of green solvents, green materials, and green catalysts. The Deep Eutectic Solvent (DES) has no or significantly less harmful effect as compared to conventional solvents. In this study we developed one-pot synthetic strategies for synthesis of different N-heterocyclic scaffolds such as indoles, 1,4-dihydropyridine, acridine, and quinoline in piperidinium bromide and fluoride-based DES; these solvents have good characteristics as multicomponent reaction media, and as a catalytic solvent to give good product yield in short interval of time.