Water-Promoted Synthesis of Enaminones: Mechanism Investigation and Application in Multicomponent Reactions

被引：54
|
作者：
Liu, Yunyun [1 ]
Zhou, Rihui [1 ]
Wan, Jie-Ping [1 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 18期
关键词：
Enaminone; green synthesis; mechanism; multicomponent; water promotion; AMINES; ESTERS; ALPHA; ACID;
D O I：
10.1080/00397911.2012.715712
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Highly stereoselective synthesis of Z-enaminones bearing reactive secondary amino group has been successfully performed in water using tertiary amino group functionalized enaminones under ambient conditions. An interesting promotion effect of water on the reaction via hydrolysis-dehydration condensation has been observed through a designed isotope labeling experiment. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
引用
收藏
页码：2475 / 2483
页数：9
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