Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides

被引：8
|
作者：
Esteban, AI
DeClercq, E
Martinez, A
机构：
[1] CSIC, INST QUIM MED, E-28006 MADRID, SPAIN
[2] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 03期
关键词：
D O I：
10.1080/07328319708001347
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.
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页码：265 / 276
页数：12
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