Enantioselective Synthesis of Tetrahydroisoquinolines via Iridium-Catalyzed Intramolecular Friedel-Crafts-Type Allylic Alkylation of Phenols

被引：46
|
作者：
Xu, Qing-Long [1 ]
Dai, Li-Xin [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 10期
基金：
中国国家自然科学基金;
关键词：
O-ALLYLATION; ASYMMETRIC-SYNTHESIS; CHIRAL CHROMANS; C-ALLYLATION; ETHERIFICATION; COMPLEXES; ALCOHOLS; SUBSTITUTIONS; CARBONATES; BONDS;
D O I：
10.1021/ol3008793
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient iridium-catalyzed intramolecular Friedel-Crafts-type allylic alkylation reaction of phenols was developed, affording tetrahydro-isoquinolines with moderate to excellent yields, enantioselectivity, and good regioselectivity.
引用
收藏
页码：2579 / 2581
页数：3
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