Methods for purifying and detoxifying sodium dodecyl sulfate-stabilized polyacrylate nanoparticles

被引：30
|
作者：
Garay-Jimenez, Julio C. [1 ]
Young, Ashley [2 ]
Gergeres, Danielle [1 ]
Greenhalgh, Kerriann [1 ]
Turos, Edward [1 ]
机构：
[1] Univ S Florida, Dept Chem, Ctr Mol Divers Drug Design Discovery & Delivery, Tampa, FL 33620 USA
[2] Nanopharma Technol Inc, Tampa, FL USA
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2008年 / 4卷 / 02期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Polyacrylate nanoparticles; Emulsions; Cytotoxicity; Sodium dodecyl sulfate;
D O I：
10.1016/j.nano.2008.03.004
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Recent research in our laboratory has centered on studies of polyacrylate and polyacrylamide nanoparticle emulsions for use in antibiotic delivery. Our goal is to develop these nanoparticle emulsions for treatment of life-threatening bacterial infections such as those caused by methicillin-resistant Staphylococcus aureus. For this intended application it is necessary to ensure that the biological activity of the emulsion is due only to the drug attached to the polymeric chain and not to any extraneous components. To investigate this we evaluated cytotoxicity and microbiological activity of the nanoparticle emulsions before and after purification by centrifugation, dialysis, and gel filtration. Depending on the amount of surfactant used, all or most of the microbial and cellular toxicity can be removed by a simple purification procedure. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：98 / 105
页数：8
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