Gene frequencies of HPA-1 and HPA-2 systems and potential risk of allo-immunization in a Tunisian population

被引：0
|
作者：
Jedidi, I. [1 ]
Romdhane, H. [1 ]
Chakroun, T. [1 ]
Abdelkefi, S. [1 ]
Houissa, B. [1 ]
Jerray, I. [1 ]
Bouslama, M. [1 ]
Yacoub, S. Jemni [1 ]
机构：
[1] Hop Farhat Hached, Ctr Reg Transfus Sanguine, Sousse 4000, Tunisia
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2013年 / 28卷 / 2-3期
关键词：
Human platelet antigen (HPA); PCR-SSP; Allele frequency; Genotype frequency; Potential risk of alto-immunization; PLATELET ANTIGEN FREQUENCIES; PCR; ALLOANTIGENS;
D O I：
10.1016/j.immbio.2012.12.005
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Allele and genotype frequencies of HPA-1 and HPA-2 systems in a Tunisian population were determined by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 100 volunteer blood donors. The risk of alto-immunization in these systems has subsequently been evaluated. This work shows a higher HPA-1b (0.195) and HPA-2b (0.150) allelic frequency, which can be responsible for the potential risk of alto-immunization in HPA-1 and HPA-2 systems in case of pregnancy or transfusion. (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：115 / 119
页数：5
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