Non-alcoholic fatty liver disease in obese children and adolescents

被引：1

作者：

Denzer, C. ^{[1
]}

机构：

[1] Univ Klin Kinder & Jugendmed, Sekt Padiatr Endokrinol & Diabetol, D-89075 Ulm, Germany

来源：

BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ | 2013年 / 56卷 / 04期

关键词：

Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Childhood obesity; Insulin resistance; Visceral adipose tissue; LIFE-STYLE INTERVENTION; METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC STEATOSIS; VITAMIN-E; ADIPONECTIN LEVELS; SERUM ALANINE; FOLLOW-UP; STEATOHEPATITIS; PREVALENCE;

D O I：

10.1007/s00103-012-1639-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and adolescents in industrialized countries. Recent studies have demonstrated a prevalence rate of NAFLD in overweight and obese children and adolescents in Germany of up to 30%. The spectrum of NAFLD ranges from pure fatty infiltration (simple steatosis) to inflammation (steatohepatitis, synonymous NASH) to fibrosis and cirrhosis. Age, gender, ethnicity, insulin resistance, and sex steroids are implicated in the pathogenesis of NAFLD in childhood and adolescence. Moreover, NAFLD in the pediatric age group is associated with marked cardiovascular comorbidities. This review focuses on current data regarding epidemiology, pathophysiology, comorbidities, and treatment of NAFLD in children and adolescents.

引用

页码：517 / 527

页数：11

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