Melatonin protects against cardiac toxicity of doxorubicin in rat

被引：30

作者：

Xu, MF ^{[1
]}

Ho, S ^{[1
]}

Qian, ZM ^{[1
]}

Tang, PL ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Chem & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF PINEAL RESEARCH | 2001年 / 31卷 / 04期

关键词：

cardiac contractile function; doxorubicin; lipid peroxidation; melatonin;

D O I：

10.1034/j.1600-079X.2001.310403.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Doxorubicin (DOX) is commonly used for the treatment of hematological and solid tumors. However, there are serious toxic effects on the cardiovascular system. which limits the application of the drug. Recently, melatonin has been reported to have immunomodulatory effect in addition to lowering cholesterol levels as well as inhibiting malignant tumors. In this study, the effect of melatonin against the toxicity of doxorubicin was investigated in rats. Hemodynamic function. pathological and biochemical changes were determined in different treated hearts. Our findings showed that a significant protection by melatonin (6 mg kg(-1) for 15 days, cumulative dose of 90 mg kg(-1)) against the DOX-induced toxicity was observed. Cardiac function was improved and lipid peroxidation decreased after melatonin treatment. It is concluded that melatonin provides protection against doxorubicin toxicity via an attenuation of lipid peroxidation.

引用

页码：301 / 307

页数：7

共 50 条

[21] Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction
Hydock, David S.
Lien, Chia-Ying
Schneider, Carole M.
Hayward, Reid
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (05): : 808 - 817
[22] A calcium antagonist protects against doxorubicin-induced impairment of calcium handling in neonatal rat cardiac myocytes
Maeda, A
Honda, M
Kuramochi, T
Takabatake, T
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1999, 63 (02): : 123 - 129
[23] Adrenomedullin protects rat dorsal root ganglion neurons against doxorubicin-induced toxicity by ameliorating oxidative stress
Mahmoodazdeh, Amir
Shafiee, Sayed Mohammad
Sisakht, Mohsen
Khoshdel, Zahra
Takhshid, Mohammad Ali
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2020, 23 (09) : 1197 - 1206
[24] Melatonin protects fetal rat brain against oxidative mitochondrial damage
Wakatsuki, A
Okatani, Y
Shinohara, K
Ikenoue, N
Kaneda, C
Fukaya, T
JOURNAL OF PINEAL RESEARCH, 2001, 30 (01) : 22 - 28
[25] Melatonin protects against oxidative organ injury in a rat model of sepsis
Sener, G
Toklu, H
Kapucu, C
Ercan, F
Erkanli, G
Kaçmaz, A
Tilki, M
Yegen, BÇ
SURGERY TODAY, 2005, 35 (01) : 52 - 59
[26] Melatonin Protects Against Oxidative Organ Injury in a Rat Model of Sepsis
Göksel Şener
Hale Toklu
Caner Kapucu
Feriha Ercan
Gözde Erkanlı
Ayhan Kaçmaz
Metin Tilki
Berrak Ç. Yeğen
Surgery Today, 2005, 35 : 52 - 59
[27] Effect of melatonin and its combination with therapeutic exercise on Doxorubicin-induced cardiac toxicity
Lkhagvasuren, Tserentogtokh
Lee, Seunghoon
Hong, Jeong-Hwa
Hong, Yonggeun
FASEB JOURNAL, 2012, 26
[28] The human amniotic fluid-derived stem cell secretome protects cardiomyocytes cardiac progenitor cells against doxorubicin toxicity
Lazzarini, E.
Balbi, C.
Altieri, P.
Magni, M.
Coviello, D.
Bosco, M. C.
Varesio, L.
Spallarossa, P.
Canepa, M.
Gambini, E.
Pompilio, G.
Cancedda, R.
Brunelli, C.
Bollini, S.
Ameri, P.
VASCULAR PHARMACOLOGY, 2015, 75 : 59 - 59
[29] Pifithrin-α protects against doxorubicin-induced apoptosis and cardiac injury
Liu, XW
Chua, CC
Chen, ZY
Landy, CL
Wu, G
Hamdy, R
Chua, BHL
CIRCULATION, 2002, 106 (19) : 350 - 350
[30] Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin
Toffoli, Giuseppe
Hadla, Mohamad
Corona, Giuseppe
Caligiuri, Isabella
Palazzolo, Stefano
Semeraro, Sabrina
Gamini, Amelia
Canzonieri, Vincenzo
Rizzolio, Flavio
NANOMEDICINE, 2015, 10 (19) : 2963 - 2971

← 1 2 3 4 5 →