Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

被引：135
|
作者：
Klein, Stefanie [1 ,2 ]
Sommer, Anja [1 ,2 ]
Distel, Luitpold V. R. [3 ]
Neuhuber, Winfried [4 ]
Kryschi, Carola [1 ,2 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen, Germany
[2] Univ Erlangen Nurnberg, ICMM, D-91058 Erlangen, Germany
[3] Univ Erlangen Nurnberg, Dept Radiat Oncol, D-91054 Erlangen, Germany
[4] Univ Erlangen Nurnberg, Dept Anat, Chair Anat 1, D-91054 Erlangen, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 425卷 / 02期
关键词：
Fenton reaction; Haber-Weiss reaction; Radiosensitizer; Reactive oxygen species; Superparamagnetic iron oxide nanoparticles; MAGNETIC NANOPARTICLES; IN-VIVO; CANCER; CYTOTOXICITY; MECHANISM; TOXICITY; RADICALS; THERAPY; CELLS;
D O I：
10.1016/j.bbrc.2012.07.108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging. Cytotoxicity studies employing metabolic and trypan blue assays manifested their excellent biocompatibility. The production of reactive oxygen species in iron oxide nanoparticle loaded MCF-7 cells was explained to originate from both, the release of iron ions and their catalytically active surfaces. Both initiate the Fenton and Haber-Weiss reaction. Additional oxidative stress caused by X-ray irradiation of MCF-7 cells was attributed to the increase of catalytically active iron oxide nanoparticle surfaces. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：393 / 397
页数：5
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