Mesoporous Bioactive Glass Nanoparticles in the SiO2-P2O5-CaO-MO (M=Mg, Zn) System: Synthesis and Properties

被引:8
|
作者
Damian-Buda, Andrada-Ioana [1 ]
Ghitulica, Cristina-Daniela [2 ]
Cucuruz, Andreia [1 ]
Voicu, Georgeta [2 ]
Culita, Daniela [3 ]
Fruth-Oprisan, Victor [3 ]
Ciocan, Lucian Toma [4 ]
机构
[1] Univ Politehn Bucuresti, Fac Med Engn, Dept Biomat & Med Devices, 1-7 Gh Polizu St, RO-060042 Bucharest, Romania
[2] Univ Politehn Bucuresti, Fac Chem Engn & Biotechnol, Dept Sci & Engn Oxide Mat & Nanomat, 1-7 Gh Polizu St, RO-060042 Bucharest, Romania
[3] Inst Phys Chem Ilie Murgulescu, Splaiul Independentei 202, RO-060021 Bucharest, Romania
[4] Carol Davila Univ Med & Pharm, Dept Prosthet Technol & Dent Mat, 8 Eroii Sanit St, RO-050474 Bucharest, Romania
关键词
nanoparticles; mesoporous bioactive glass; antibacterial activity; CELLS; SOL;
D O I
10.3390/jfb13040180
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Mesoporous bioactive glass nanoparticles (MBGNs) are widely recognized for their ability to bond to hard tissue, while the ions released from the BG structure enhance specific cellular pathways. In this study, the SiO2-P2O5-CaO-MgO-ZnO system was used to successfully synthesize MBGNs by a microemulsion-assisted sol-gel method. The MBGNs calcinated at 600 degrees C/3 h had a typical phosphosilicate structure together with a poorly crystalline hydroxyapatite (HAp). The addition of ZnO not only led to a higher degree of crystallinity of HAp but also induced a higher porosity of the particles. All MBGNs had a mesoporous structure with an interconnected network of slit shape pores. For each type of composition, two families of highly dispersed spherical nanoparticles could be identified. In vitro tests in simulated body fluid (SBF) proved that after only 3 days of immersion all the materials were covered with a layer of brushite whose degree of crystallinity decreases in the presence of Zn2+. The antibacterial assay revealed a strong inhibitory effect for all samples after 40 h of contact. Simultaneously, MBGNs did not increase the intracellular oxidative stress while it stimulated the cell proliferation process.
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页数:15
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