A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties

被引：6
|
作者：
Subramanian, M
Chander, R
Chattopadhyay, S [1 ]
机构：
[1] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
[2] Bhabha Atom Res Ctr, Div Food Technol, Bombay 400085, Maharashtra, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 08期
关键词：
copper; DNA; prodigiosin analogue; nuclease; redox;
D O I：
10.1016/j.bmc.2005.11.062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The DNA targeting and membrane damaging activities of a novel tripyrrole 1 obtained as a red pigment from the Micrococcus sp. were investigated. It was found that compound 1 binds with DNA efficiently and facilitates copper-mediated DNA cleavage as well as peroxidation of membrane lipids by a process that does not require any external reducing agent. Compound 1 also showed impressive cytotoxicity to both mouse and human tumour cell lines. The membrane damaging ability of compound 1 might be vital in its nuclease and cytotoxicity properties. Interestingly, compared to the various DNA cleaving agents, compound 1 showed a preferential binding with the G-C rich domain. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2480 / 2486
页数：7
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