Enantioselective Catalytic Synthesis ofN-alkylated Indoles

被引：18
|
作者：
Trubitson, Dmitri [1 ]
Kanger, Tonis [1 ]
机构：
[1] Tallinn Univ Technol, Sch Sci, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia
来源：
SYMMETRY-BASEL | 2020年 / 12卷 / 07期
关键词：
indole; asymmetric synthesis; organocatalysis; transition-metal catalysis; C-N bond formation; enantioselective; heterocycles; FRIEDEL-CRAFTS ALKYLATION; N-ALKYLATION; NITROGEN-HETEROCYCLES; ALLYLIC ALKYLATION; FUNCTIONALIZATION; HYDROAMINATION; DIVERSITY; PYRROLES; CASCADE;
D O I：
10.3390/sym12071184
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
During the past two decades, the interest in new methodologies for the synthesis of chiralN-functionalized indoles has grown rapidly. The review illustrates efficient applications of organocatalytic and organometallic strategies for the construction of chiral alpha-N-branched indoles. Both the direct functionalization of the indole core and indirect methods based on asymmetricN-alkylation of indolines, isatins and 4,7-dihydroindoles are discussed.
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页数：30
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