Gas chromatographic mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples

被引：20
|
作者：
Musshoff, F [1 ]
Daldrup, T [1 ]
机构：
[1] UNIV DUSSELDORF,INST LEGAL MED,D-40225 DUSSELDORF,GERMANY
来源：
FORENSIC SCIENCE INTERNATIONAL | 1997年 / 88卷 / 02期
关键词：
lysergic acid diethylamide (LSD); gas chromatography mass spectrometry; analytical backdrops;
D O I：
10.1016/S0379-0738(97)00063-7
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography - mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml(-1). Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：133 / 140
页数：8
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