The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

被引：139
|
作者：
Kobilka, Brian [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 25期
基金：
美国国家卫生研究院;
关键词：
2 adrenergic receptor; G protein coupled receptors; Nobel lecture; protein structures; signaling; BETA(2) ADRENERGIC-RECEPTOR; CRYSTAL-STRUCTURE; TRANSMEMBRANE DOMAINS; MEMBRANE; ACTIVATION; AGONISTS; BINDING; BETA(2)-ADRENOCEPTOR; CRYSTALLIZATION; RHODOPSIN;
D O I：
10.1002/anie.201302116
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cells from different parts of our bodies communicate with each other using chemical messengers in the form of hormones and neurotransmitters. They process information encoded in these chemical messages using G-protein-coupled receptors (GPCRs) located in the plasma membrane. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6380 / 6388
页数：9
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