The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

被引：139
|
作者：
Kobilka, Brian [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 25期
基金：
美国国家卫生研究院;
关键词：
2 adrenergic receptor; G protein coupled receptors; Nobel lecture; protein structures; signaling; BETA(2) ADRENERGIC-RECEPTOR; CRYSTAL-STRUCTURE; TRANSMEMBRANE DOMAINS; MEMBRANE; ACTIVATION; AGONISTS; BINDING; BETA(2)-ADRENOCEPTOR; CRYSTALLIZATION; RHODOPSIN;
D O I：
10.1002/anie.201302116
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cells from different parts of our bodies communicate with each other using chemical messengers in the form of hormones and neurotransmitters. They process information encoded in these chemical messages using G-protein-coupled receptors (GPCRs) located in the plasma membrane. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6380 / 6388
页数：9
相关论文
共 50 条
  • [1] Nobel Lecture - Structural insights into G protein coupled receptor signaling
    Kobilka, B.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2014, 17 : 1 - 1
  • [2] Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
    Ron O. Dror
    Hillary F. Green
    Celine Valant
    David W. Borhani
    James R. Valcourt
    Albert C. Pan
    Daniel H. Arlow
    Meritxell Canals
    J. Robert Lane
    Raphaël Rahmani
    Jonathan B. Baell
    Patrick M. Sexton
    Arthur Christopoulos
    David E. Shaw
    Nature, 2013, 503 : 295 - 299
  • [3] Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
    Dror, Ron O.
    Green, Hillary F.
    Valant, Celine
    Borhani, David W.
    Valcourt, James R.
    Pan, Albert C.
    Arlow, Daniel H.
    Canals, Meritxell
    Lane, J. Robert
    Rahmani, Raphael
    Baell, Jonathan B.
    Sexton, Patrick M.
    Christopoulos, Arthur
    Shaw, David E.
    NATURE, 2013, 503 (7475) : 295 - +
  • [4] Structural Basis for G Protein-Coupled Receptor Signaling
    Erlandson, Sarah C.
    McMahon, Conor
    Kruse, Andrew C.
    ANNUAL REVIEW OF BIOPHYSICS, VOL 47, 2018, 47 : 1 - 18
  • [5] G-Protein-Coupled Receptor Signaling in Cilia
    Mykytyn, Kirk
    Askwith, Candice
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2017, 9 (09):
  • [6] Structural Basis of Lipid Effects on G-Protein-Coupled Receptor (GPCR) Activation
    Huber, Thomas
    Sakmar, Thomas P.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 592A - 593A
  • [7] The structural basis of G-protein-coupled receptor function and dysfunction in human diseases
    Schöneberg, T
    Schulz, A
    Gudermann, T
    REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, VOL 144, 2002, 144 : 143 - 227
  • [8] Structural basis for activation of G-protein-coupled receptors
    Gether, U
    Asmar, F
    Meinild, AK
    Rasmussen, SGF
    PHARMACOLOGY & TOXICOLOGY, 2002, 91 (06): : 304 - 312
  • [9] Chemosensory G-protein-coupled receptor signaling in the brain
    Woodard, GE
    INTERNATIONAL REVIEW OF NEUROBIOLOGY, VOL 62, 2004, 62 : 147 - 157
  • [10] Hydration Modulates G-Protein-Coupled Receptor Signaling
    Fried, Steven D. E.
    Eitel, Anna R.
    Weerasinghe, Nipuna
    Norris, Carolanne E.
    Vos, Margaret R.
    Somers, Johnathan D.
    Fitzwater, Gabrielle I.
    Pitman, Michael C.
    Struts, Andrey V.
    Perera, Suchithranga M. D. C.
    Brown, Michael F.
    FASEB JOURNAL, 2019, 33
12345