Copper-Catalyzed Regioselective Hydroalkylation of 1,3-Dienes with Alkyl Fluorides and Grignard Reagents

被引：39
|
作者：
Iwasaki, Takanori [1 ]
Shimizu, Ryohei [1 ]
Imanishi, Reiko [1 ]
Kuniyasu, Hitoshi [1 ]
Kambe, Nobuaki [1 ]
机构：
[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 32期
关键词：
alkylation; chemoselectivity; copper; magnesium; synthetic methods; CROSS-COUPLING REACTION; F BOND ACTIVATION; CARBONYL-COMPOUNDS; 1,4-ARYLATION ALKYLATION; TRANSFER HYDROGENATION; METAL-COMPLEXES; HALIDES; NICKEL; DIENES; ALCOHOL;
D O I：
10.1002/anie.201503288
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper complexes generated insitu from CuCl2, alkyl Grignard reagents, and 1,3-dienes play important roles as catalytic active species for the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides through CF bond cleavage. The alkyl group is introduced to an internal carbon atom of the 1,3-diene regioselectively, thus giving rise to the branched terminal alkene product.
引用
收藏
页码：9347 / 9350
页数：4
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