Stereocontrolled Total Synthesis of (-)-Englerin A

被引：41
|
作者：
Takahashi, Keisuke [1 ]
Komine, Keita [1 ]
Yokoi, Yuichi [1 ]
Ishihara, Jun [1 ]
Hatakeyama, Susumi [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 17期
关键词：
FORMAL SYNTHESIS; MAGNESIUM MONOPERPHTHALATE; EPOXYNITRILE CYCLIZATION; BIOLOGICAL EVALUATION; OXIDATION; STEREOCHEMISTRY; CYCLOADDITION; ENGLERIN; INDIUM;
D O I：
10.1021/jo301145r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of (-)-englerin A, a potent and selective inhibitor of renal cancer cell lines, is described. The key feature indudes the stereocontrolled construction of the cyclopentane structure by taking advantage of a base-promoted epoxynitrile cyclization.
引用
收藏
页码：7364 / 7370
页数：7
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