Stereocontrolled Total Synthesis of (-)-Englerin A

被引：41

作者：

Takahashi, Keisuke ^{[1
]}

Komine, Keita ^{[1
]}

Yokoi, Yuichi ^{[1
]}

Ishihara, Jun ^{[1
]}

Hatakeyama, Susumi ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 17期

关键词：

FORMAL SYNTHESIS; MAGNESIUM MONOPERPHTHALATE; EPOXYNITRILE CYCLIZATION; BIOLOGICAL EVALUATION; OXIDATION; STEREOCHEMISTRY; CYCLOADDITION; ENGLERIN; INDIUM;

D O I：

10.1021/jo301145r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of (-)-englerin A, a potent and selective inhibitor of renal cancer cell lines, is described. The key feature indudes the stereocontrolled construction of the cyclopentane structure by taking advantage of a base-promoted epoxynitrile cyclization.

引用

页码：7364 / 7370

页数：7

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