Effect of Weight Extremes on Ventricular Volumes and Myocardial Strain in Repaired Tetralogy of Fallot as Measured by CMR

被引:14
|
作者
Simpson, Scott A. [1 ]
Field, Suzanne L. [2 ]
Xu, Meng [3 ]
Saville, Benjamin R. [3 ]
Parra, David A. [4 ]
Soslow, Jonathan H. [4 ]
机构
[1] Univ Mississippi, Med Ctr, Dept Pediat, Div Pediat Cardiol, Jackson, MS 39216 USA
[2] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA
[4] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Cardiol, 2200 Childrens Way,Suite 5230 Doctors Off Tower, Nashville, TN 37232 USA
基金
美国国家卫生研究院;
关键词
Tetralogy of Fallot; Cardiac magnetic resonance; Obesity; Body Mass Index; Body surface area; Strain; PULMONARY VALVE-REPLACEMENT; BODY-MASS INDEX; CONGENITAL HEART-DISEASE; MAGNETIC-RESONANCE; RISK-FACTORS; OBESITY; CHILDREN; ADULTS; IMPACT; REGURGITATION;
D O I
10.1007/s00246-017-1793-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot (rTOF-TAP) is often based on cardiac MRI (CMR) right ventricular (RV) volumes indexed to body surface area (BSA). Weight extremes result in increased patient morbidity and affect indexed measurements. We hypothesized that patients with rTOF-TAP at extremes of weight have (1) over- or underestimated indexed volumes and (2) altered parameters of cardiac function. CMRs in patients with rTOF-TAP were retrospectively reviewed; analysis included right and left ventricular (LV) volumes and ejection fractions (EF) and peak global LV circumferential strain (epsilon (cc)) from myocardial tagged images. Indexed volumes were recalculated using ideal BSA. Weight categories were assigned: underweight, appropriate weight, overweight, and obese. Linear regression models with weight category, spline of age, and gender were created to assess the association of weight and parameters of volume and function. When RV volumes were corrected for ideal BSA, 11 (31%) additional overweight and obese patients met published criteria for PVR and 3 (38%) underweight patients no longer met criteria. Obese and overweight patients had larger absolute LV and RV diastolic volumes, but no difference in volumes indexed to ideal BSA. Modeling demonstrated no difference in LVEF or RVEF by weight categories but significant differences in global LV epsilon (cc). Extremes of body weight may result in inappropriate timing of PVR. Extremes of weight lead to abnormalities in global LV epsilon (cc). Although clinical implications of abnormal epsilon (cc) are unclear, these patients may be at higher risk for early ventricular dysfunction.
引用
收藏
页码:575 / 584
页数:10
相关论文
共 50 条
  • [31] Prognostic value of left ventricular rotation and strain in adult patients with repaired tetralogy of Fallot
    Van Grootel, R. W. J.
    Van Den Bosch, A. E.
    Baggen, V. J. M.
    Menting, M. E.
    Cuypers, J. A. A. E.
    Witsenburg, M.
    Roos-Hesselink, J. W.
    EUROPEAN HEART JOURNAL, 2018, 39 : 425 - 426
  • [32] A comparison of right ventricular volumes in children and adults with repaired tetralogy of Fallot - including and excluding right ventricular trabeculations
    James D Enos
    Jacob Hartz
    Rachel Quinn
    Lasya Gaur
    Russell Cross
    Laura Olivieri
    Journal of Cardiovascular Magnetic Resonance, 18 (Suppl 1)
  • [33] Pulmonary and ventricular functions in children with repaired tetralogy of Fallot
    Demirpence, Savas
    Guven, Baris
    Yilmazer, Murat Muhtar
    Oner, Taliha
    Doksoz, Onder
    Ozdemir, Rahmi
    Nacaroglu, Hikmet Tekin
    Mese, Timur
    Tavli, Vedide
    Can, Demet
    TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, 2015, 43 (06): : 542 - 550
  • [34] PROGRESSION OF RIGHT VENTRICULAR DILATION IN REPAIRED TETRALOGY OF FALLOT
    Leonardi, Benedetta
    Ait-Alia, Lamia
    Chinali, Marcello
    Festa, Pierluigi
    Secinaro, Aurelio
    Pongiglione, Giacomo
    Gesu, Bambino
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (10) : A556 - A556
  • [35] Progression of Right Ventricular Dilation in Repaired Tetralogy of Fallot
    Buddhe, Sujatha
    Shah, Amee
    Lai, Wyman W.
    JOURNAL OF MAGNETIC RESONANCE IMAGING, 2015, 41 (03) : 730 - 737
  • [36] Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot
    Zhong, Liang
    Gobeawan, Like
    Su, Yi
    Tan, Ju-Le
    Ghista, Dhanjoo
    Chua, Terrance
    Tan, Ru-San
    Kassab, Ghassan
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2012, 302 (06): : H1306 - H1316
  • [37] The value of myocardial strain imaging in the evaluation of patients with repaired Tetralogy of Fallot: a review of the literature
    Panagiotis Zachos
    Vasilios Nevras
    Nikias Milaras
    Maria Karakosta
    Alkistis Kalesi
    Nearchos Kasinos
    Antonios Destounis
    Nikolaos L. Kelekis
    Ignatios Ikonomidis
    Dimitrios Niakas
    Heart Failure Reviews, 2023, 28 : 97 - 112
  • [38] Assessment of ventricular function in adults with repaired Tetralogy of Fallot using myocardial deformation imaging
    Menting, Myrthe E.
    van den Bosch, Annemien E.
    McGhie, Jackie S.
    Eindhoven, Jannet A.
    Cuypers, Judith A. A. E.
    Witsenburg, Maarten
    Geleijnse, Marcel L.
    Helbing, Willem A.
    Roos-Hesselink, Jolien W.
    EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2015, 16 (12) : 1347 - 1357
  • [39] Right ventricular free wall strain predicts quality of life in repaired tetralogy of Fallot
    Jimmy C Lu
    Maryam Ghadimi Mahani
    Prachi Agarwal
    Adam L Dorfman
    Journal of Cardiovascular Magnetic Resonance, 15 (Suppl 1)
  • [40] The value of myocardial strain imaging in the evaluation of patients with repaired Tetralogy of Fallot: a review of the literature
    Zachos, Panagiotis
    Nevras, Vasilios
    Milaras, Nikias
    Karakosta, Maria
    Kalesi, Alkistis
    Kasinos, Nearchos
    Destounis, Antonios
    Kelekis, Nikolaos L.
    Ikonomidis, Ignatios
    Niakas, Dimitrios
    HEART FAILURE REVIEWS, 2023, 28 (01) : 97 - 112