Acute T-lymphoblastic leukemia relapsed with the character of myeloid/natural killer cell precursor phenotype: a case report

被引：8

作者：

Hashimoto, S ^{[1
]}

Toba, K ^{[1
]}

Aoki, S ^{[1
]}

Tsuchiyama, J ^{[1
]}

Tsukada, N ^{[1
]}

Takahashi, H ^{[1
]}

Takahashi, M ^{[1
]}

Aizawa, Y ^{[1
]}

机构：

[1] Niigata Univ, Sch Med, Dept Internal Med 1, Niigata 9518510, Japan

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 02期

关键词：

T-acute lymphoblastic leukemia; myeloid natural killer cell precursor acute leukemia; pro-T lymphoblast; acute leukemia; CD3; epsilon; CD56;

D O I：

10.1016/S0145-2126(01)00088-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The leukemic lymphoblasts or a patient expressed CD7, CD13, CD33, CD34, HLA-DR and cytoplasmic CD3epsilon. He was diagnosed with acute lymphoblastic leukemia (ALL), and successfully treated with a conventional chemotherapy for ALL. The disease relapsed three times, and the character of the cells gradually altered, i.e. CD-56 expression increased and CD13, CD7 and cCD3epsilon decreased. The phenotype of the relapsed ALL was. therefore, compatible with myeloid/natural killer cell precursor acute leukemia (M/NK-AL). Some of M/NK-AL may be closely related with T/myeloid-biphenotypic pro-T blasts, and both types of acute leukemia may develop a tendency to express myeloid antigens, and they may belong to the category of immature T lymphoid precursors. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：215 / 219

页数：5

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