Acute T-lymphoblastic leukemia relapsed with the character of myeloid/natural killer cell precursor phenotype: a case report

被引：8
|
作者：
Hashimoto, S [1 ]
Toba, K [1 ]
Aoki, S [1 ]
Tsuchiyama, J [1 ]
Tsukada, N [1 ]
Takahashi, H [1 ]
Takahashi, M [1 ]
Aizawa, Y [1 ]
机构：
[1] Niigata Univ, Sch Med, Dept Internal Med 1, Niigata 9518510, Japan
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 02期
关键词：
T-acute lymphoblastic leukemia; myeloid natural killer cell precursor acute leukemia; pro-T lymphoblast; acute leukemia; CD3; epsilon; CD56;
D O I：
10.1016/S0145-2126(01)00088-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The leukemic lymphoblasts or a patient expressed CD7, CD13, CD33, CD34, HLA-DR and cytoplasmic CD3epsilon. He was diagnosed with acute lymphoblastic leukemia (ALL), and successfully treated with a conventional chemotherapy for ALL. The disease relapsed three times, and the character of the cells gradually altered, i.e. CD-56 expression increased and CD13, CD7 and cCD3epsilon decreased. The phenotype of the relapsed ALL was. therefore, compatible with myeloid/natural killer cell precursor acute leukemia (M/NK-AL). Some of M/NK-AL may be closely related with T/myeloid-biphenotypic pro-T blasts, and both types of acute leukemia may develop a tendency to express myeloid antigens, and they may belong to the category of immature T lymphoid precursors. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：215 / 219
页数：5
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