Influence of methylphenidate on circadian rhythmicity and sleep in adult attention-deficit/hyperactivity disorder

被引：6

作者：

Snitselaar, Mark A.

Smits, Marcel G. ^{[1
]}

van der Heijden, Kristiaan B. ^{[2
,3
]}

Smit, Annet ^{[4
]}

Spijker, Jan ^{[5
,6
]}

机构：

[1] Gelderse Vallei Hosp, Ctr Sleep Disturbances & Chronobiol, Ede, Netherlands

[2] Leiden Univ, Inst Brain & Cognit, Leiden, Netherlands

[3] Leiden Univ, Inst Educ & Child Studies, Leiden, Netherlands

[4] Pro Persona Ctr Educ & Sci, Nijmegen, Netherlands

[5] Pro Persona Mental Hlth Care, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands

来源：

SLEEP AND BIOLOGICAL RHYTHMS | 2013年 / 11卷 / 04期

关键词：

adult; attention-deficit; hyperactivity disorder; circadian rhythm; dim light melatonin onset; methylphenidate; sleep; MELATONIN; CHILDREN;

D O I：

10.1111/sbr.12033

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To explore the effect of methylphenidate on sleep and circadian rhythmicity, actigraphic sleep-wake rhythm, Dim Light Melatonin Onset (DLMO), Phase Angle Difference (PAD; time between DLMO and mid-sleep) and attention-deficit/hyperactivity disorder (ADHD) Rating Scale were assessed before and after 4-week treatment with methylphenidate in 10 adults with ADHD. During methylphenidate treatment DLMO did not change, while melatonin concentration at 23.00 hours increased. Phase advance type (PAD > 6h) before treatment was associated with a greater treatment-related reduction in attention symptoms. These results suggest that PAD > 6h might have a predictive value for the effect of methylphenidate.

引用

页码：282 / 285

页数：4

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