Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium

被引：14

作者：

Minamisawa, S

Uemura, N

Sato, Y

Yokoyama, U

Yamaguchi, T

Inoue, K

Nakagome, M

Bai, YZ

Hori, H

Shimizu, M

Mochizuki, S

Ishikawa, Y

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Phys, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Phys, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[3] Natl Inst Hlth Sci, Div Cellular & Gene Therapy Prod, Setagaya Ku, Tokyo 1588501, Japan

[4] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Med Cardiol, Newark, NJ 07101 USA

[5] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Cell Biol & Mol Med, Newark, NJ 07101 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 09期

关键词：

thyroid hormone; calcium; gene expression; cardiomyocyte; sarcoplasmic reticulum;

D O I：

10.1016/j.febslet.2006.03.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thyroid hormone-mediated positive cardiotropic effects are differently regulated between the atria and ventricles. This regulation is, at least in part, dependent on sareoplasmic reticulum (SR) proteins. Sarcolipin, a homologue of phospholamban, has been recently identified as an atrium-specific SR protein. The expression of sarcolipin mRNA was significantly decreased in the atria of mice with hyperthyroidism and in 3,5,3'-triiodo-(L)-thyronine-treated neonatal rat atrial myocytes. Promoter activity and mRNA stability analyses revealed that thyroid hormone post-transcriptionally downregulated the expression of sarcolipin mRNA. The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2247 / 2252

页数：6

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