Nine polymorphic STR loci in the HLA region in the Shaanxi Han population of China

被引：2
|
作者：
Zhang, H. B. [1 ,2 ]
Wei, S. G. [1 ,2 ]
Yu, B. [1 ,2 ]
Li, L. [1 ,2 ]
Lai, J. H. [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Med, Natl Minist Hlth Forens Sci, Key Lab, Xian 710049, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Med, Minist Educ, Key Lab Environm & Gene Related Dis, Xian 710049, Shaanxi, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2012年 / 11卷 / 03期
关键词：
HLA; STR; Polymorphisms; Han population genetics; PREIMPLANTATION GENETIC DIAGNOSIS; SHORT TANDEM REPEATS; MHC REGION; MICROSATELLITES;
D O I：
10.4238/2012.July.10.8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A large number of microsatellite genetic markers have been identified in the human leukocyte antigen (HLA) region. We investigated genetic polymorphism of the nine short tandem repeat (STR) loci (D6S276, MOGCA, D6S265, MIB, D6S273, G51152, TAP1CA, RING3CA, and D6S291) in the HLA region in the Shaanxi Han population. Using a fluorescence-labeled multiplex-PCR STR typing method, 6-13 alleles were detected in these nine STR loci in 150 unrelated Han Chinese from the region of Shaanxi, China. The distributions of the genotypes at these nine loci were in Hardy-Weinberg equilibrium. We conclude that these nine STR loci have a high level of genetic polymorphism; they would be useful for population genetic studies, pre-transplantation HLA typing, forensic and paternity testing, etc.
引用
收藏
页码：2534 / 2538
页数：5
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