Altered cortico-basal ganglia motor pathways reflect reduced volitional motor activity in schizophrenia

被引:61
|
作者
Bracht, Tobias
Schnell, Susanne [2 ,3 ,4 ]
Federspiel, Andrea [1 ]
Razavi, Nadja [1 ]
Horn, Helge
Strik, Werner
Wiest, Roland [5 ]
Dierks, Thomas [1 ]
Mueller, Thomas J.
Walther, Sebastian [1 ]
机构
[1] Univ Bern, Univ Hosp Psychiat, Dept Psychiat Neurophysiol, CH-3000 Bern 60, Switzerland
[2] Univ Med Ctr Freiburg, Dept Diagnost Radiol, D-79106 Freiburg, Germany
[3] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
[4] Northwestern Univ, Feinberg Sch Med, Dept Biomed Engn, Chicago, IL 60611 USA
[5] Univ Bern, Inselspital, Inst Diagnost & Intervent Neuroradiol, CH-3010 Bern, Switzerland
关键词
Diffusion tensor imaging; White matter; Tractography; Movement disorders; Schizophrenia; Actigraphy; CEREBRAL-BLOOD-FLOW; DIFFUSION-TENSOR; 1ST-EPISODE SCHIZOPHRENIA; PARKINSONS-DISEASE; CONNECTIVITY; CORTEX; ACTIVATION; SYMPTOMS; MRI; TRACTOGRAPHY;
D O I
10.1016/j.schres.2012.12.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Little is known about the neurobiology of hypokinesia in schizophrenia. Therefore, the aim of this study was to investigate alterations of white matter motor pathways in schizophrenia and to relate our findings to objectively measured motor activity. We examined 21 schizophrenia patients and 21 healthy controls using diffusion tensor imaging and actigraphy. We applied a probabilistic fibre tracking approach to investigate pathways connecting the dorsolateral prefrontal cortex (dlPFC), the rostral anterior cingulate cortex (rACC), the pre-supplementary motor area (pre-SMA), the supplementary motor area proper (SMA-proper), the primary motor cortex (M1), the caudate nucleus, the striatum, the pallidum and the thalamus. Schizophrenia patients had lower activity levels than controls. In schizophrenia we found higher probability indices forming part of a bundle of interest (PIBI) in pathways connecting rACC, pre-SMA and SMA-proper as well as in pathways connecting M1 and pre-SMA with caudate nucleus, putamen, pallidum and thalamus and a reduced spatial extension of motor pathways in schizophrenia. There was a positive correlation between PIBI and activity level in the right pre-SMA-pallidum and the left M1-thalamus connection in healthy controls, and in the left pre-SMA-SMA-proper pathway in schizophrenia. Our results point to reduced volitional motor activity and altered motor pathway organisation in schizophrenia. The identified associations between the amount of movement and structural connectivity of motor pathways suggest dysfunction of cortico-basal ganglia pathways in the pathophysiology of hypokinesia in schizophrenia. Schizophrenia patients may use cortical pathways involving the supplementary motor area to compensate for basal ganglia dysfunction. (C) 2012 Elsevier B. V. All rights reserved.
引用
收藏
页码:269 / 276
页数:8
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