Dimeric cinchona ammonium salts with benzophenone linkers: enantioselective phase transfer catalysts for the synthesis of α-amino acids

被引：9
|
作者：
Woo, Seunga [1 ]
Kim, Yong-Gyun [1 ]
Lim, Baegeun [1 ]
Oh, Jiin [1 ]
Lee, Yeonji [1 ]
Gwon, Hyeri [1 ]
Nahm, Keepyung [1 ]
机构：
[1] Yeungnam Univ, Sch Chem & Biochem, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea
来源：
RSC ADVANCES | 2018年 / 8卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
ASYMMETRIC CATALYSIS; CHIRAL POLYMERS; SCHIFF-BASE; ALKYLATION; ALKALOIDS; ENOLATE; IMINES; STATE;
D O I：
10.1039/c7ra12499f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral phase transfer catalysts of dimeric cinchona ammonium salts linked with a benzophenone bridge showed high enantioselectivity in the alpha-alkylation of a glycinate ester under mild industry-applicable conditions: 0.5 mol% PTC and near equivalents of alkyl halide. A dual function of the dimeric quinuclidiniums was proposed for the high efficiency.
引用
收藏
页码：2157 / 2160
页数：4
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