Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

被引:0
|
作者
She, Q.-B.
Chandarlapaty, S.
Ye, Q.
Lobo, J.
Haskell, K. M.
Leander, K. R.
DeFeo-Jones, D.
Huber, H. E.
Rosen, N.
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[2] Merck Res Labs, West Point, PA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:222S / 222S
页数:1
相关论文
共 50 条
  • [31] HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway:: An unexpected effect on TRAIL-induced apoptosis
    Dubská, L
    Andera, L
    Sheard, MA
    FEBS LETTERS, 2005, 579 (19) : 4149 - 4158
  • [32] Calorie restriction reduces PI3K/Akt signaling and tumorigenic potential in HER2-overexpressing breast cancer
    Smith, Laura A.
    Rainey, Magdalena A.
    Sheth, Nishita T.
    O'Flanagan, Ciara H.
    Bowers, Laura W.
    Hursting, Stephen D.
    CANCER RESEARCH, 2018, 78 (13)
  • [33] Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells
    Zhang, Jin
    FASEB JOURNAL, 2015, 29
  • [34] More antitumor efficacy of the PI3K inhibitor GDC-0941 in breast cancer with PIK3CA mutation or HER2 amplification status in vitro
    Zheng, Jie
    Wang, Huan
    Yao, Jia
    Zou, Xianjin
    PHARMAZIE, 2014, 69 (01): : 38 - 42
  • [35] Targeting HER2 and PI3K in Uterine Serous Cancer
    Diver, E. J.
    Hernandez, S. F.
    Scaltriti, M.
    Rueda, B. R.
    Growdon, W. B.
    GYNECOLOGIC ONCOLOGY, 2015, 139 (03) : 596 - 596
  • [36] Targeting the PI3K/Akt/mTOR pathway in estrogen-receptor positive HER2 negative advanced breast cancer
    du Rusquec, Pauline
    Blonz, Cyriac
    Frenel, Jean Sebastien
    Campone, Mario
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020, 12
  • [37] PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
    Fang, Jing
    Ding, Min
    Yang, Lily
    Liu, Ling-Zhi
    Jiang, Bing-Hua
    CELLULAR SIGNALLING, 2007, 19 (12) : 2487 - 2497
  • [38] Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer
    Li, Huayi
    Prever, Lorenzo
    Hirsch, Emilio
    Gulluni, Federico
    CANCERS, 2021, 13 (14)
  • [39] hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2 overexpressing breast cancer cells
    Trono, Paola
    Di Modugno, Francesca
    Circo, Rita
    Spada, Sheila
    Melchionna, Roberta
    Palermo, Belinda
    Panetta, Mariangela
    Matteoni, Silvia
    Soddu, Silvia
    De Maria, Ruggero
    Nistico, Paola
    CANCER RESEARCH, 2015, 75
  • [40] The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination
    Balz, Lydia M.
    Bartkowiak, Kai
    Andreas, Antje
    Pantel, Klaus
    Niggemann, Bernd
    Zaenker, Kurt S.
    Brandt, Burkhard H.
    Dittmar, Thomas
    JOURNAL OF PATHOLOGY, 2012, 227 (02): : 234 - 244