Analysis of blood-based gene expression signature in first-episode psychosis

被引：17

作者：

Lee, Jimmy ^{[1
,2
,3
]}

Goh, Liang-Kee ^{[4
,5
,6
]}

Chen, Gengbo ^{[4
]}

Verma, Swapna ^{[7
]}

Tan, Chay-Hoon ^{[8
]}

Lee, Tih-Shih ^{[9
]}

机构：

[1] Woodbridge Hosp, Inst Mental Hlth, Dept Gen Psychiat 1, Singapore 539747, Singapore

[2] Woodbridge Hosp, Inst Mental Hlth, Div Res, Singapore 539747, Singapore

[3] Duke Natl Univ Singapore, Grad Sch Med, Off Clin Sci, Singapore, Singapore

[4] Duke Natl Univ Singapore, Grad Sch Med, Canc & Stem Cell Biol Program, Singapore, Singapore

[5] Natl Canc Ctr Singapore, Dept Med Oncol, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore

[7] Woodbridge Hosp, Inst Mental Hlth, Dept Early Psychosis Intervent, Singapore 539747, Singapore

[8] Natl Univ Hlth Syst, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore, Singapore

[9] Duke Natl Univ Singapore, Grad Sch Med, Neurosci & Behav Disorders Program, Singapore, Singapore

来源：

PSYCHIATRY RESEARCH | 2012年 / 200卷 / 01期

关键词：

Transcriptome; First-episode psychosis; Blood; MICROARRAY;

D O I：

10.1016/j.psychres.2012.03.021

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood-based transcriptomic signature in psychosis is an alternative to a brain-based signature. In this study, we profiled whole-blood RNA from 26 patients with first-episode psychosis, and 26 matching controls. We identified a 400-gene signature that classified patients from controls accurately and tested the robustness using other modelling methods. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 54

页数：3

共 50 条

[31] Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis
E S Gouvea
V K Ota
C Noto
M L Santoro
L M Spindola
P N Moretti
C M Carvalho
G Xavier
A C Rios
J R Sato
M A F Hayashi
E Brietzke
A Gadelha
R A Bressan
Q Cordeiro
S I Belangero
Translational Psychiatry, 2016, 6 : e908 - e908
[32] Vocational recovery in first-episode psychosis
Ienciu, M.
Romosan, F.
Bredicean, C.
Cristanovici, M.
Hurmuz, M.
SECOND WORLD CONGRESS ON RESILIENCE: FROM PERSON TO SOCIETY, 2014, : 19 - 22
[33] Neurocognitive change in first-episode psychosis
Purvis, RG
Jones, HM
Ohlsen, RI
O'Toole, MS
Taylor, T
Pilowsky, LS
Brown, RG
SCHIZOPHRENIA RESEARCH, 2002, 53 (03) : 124 - 124
[34] Caregiver psychoeducation for first-episode psychosis
McWilliams, Stephen
Egan, Patrick
Jackson, Deirdre
Renwick, Laoise
Foley, Sharon
Behan, Caragh
Fitzgerald, Emma
Fetherston, Alastair
Turner, Niall
Kinsella, Anthony
O'Callaghan, Eadbhard
EUROPEAN PSYCHIATRY, 2010, 25 (01) : 33 - 38
[35] Smoking in first-episode psychosis patients
Chan, S
Voon, L
Chong, SA
SCHIZOPHRENIA RESEARCH, 2004, 70 (01) : 71 - 71
[36] Predictors of engagement in first-episode psychosis
Casey, Daniel
Brown, Luke
Gajwani, Ruchika
Islam, Zoebia
Jasani, Rubina
Parsons, Helen
Tah, Priya
Birchwood, Max
Singh, Swaran P.
SCHIZOPHRENIA RESEARCH, 2016, 175 (1-3) : 204 - 208
[37] Aggressive incidents in first-episode psychosis
Milton, J
Amin, S
Singh, SP
Harrison, G
Jones, P
Croudace, T
Medley, I
Brewin, J
BRITISH JOURNAL OF PSYCHIATRY, 2001, 178 : 433 - 440
[38] 'Jumping to conclusions' in first-episode psychosis
Dudley, Robert
Shaftoe, Debra
Cavanagh, Kate
Spencer, Helen
Ormrod, John
Turkington, Douglas
Freeston, Mark
EARLY INTERVENTION IN PSYCHIATRY, 2011, 5 (01) : 50 - 56
[39] INFLAMMATORY RESPONSE IN FIRST-EPISODE PSYCHOSIS
Suvisaari, Jaana
Mantyla, Teemu J. S.
Raij, Tuukka
Kieseppa, Tuula
Torniainen, Minna
Vaarala, Outi
SCHIZOPHRENIA RESEARCH, 2014, 153 : S57 - S57
[40] First-episode psychosis: A literature review
Reed, Simone I.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING, 2008, 17 (02) : 85 - 91

← 1 2 3 4 5 →