Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea

被引:22
|
作者
Tamanna, Sadeka [1 ]
Campbell, Douglas [1 ]
Warren, Richard [1 ]
Ullah, Mohammad I. [2 ]
机构
[1] GV Sonny Montgomery VA Med Ctr, Jackson, MS USA
[2] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA
来源
JOURNAL OF CLINICAL SLEEP MEDICINE | 2016年 / 12卷 / 09期
关键词
OSA; obstructive sleep apnea; GERD; nocturnal reflux; CPAP; NASAL CPAP; OBESITY; DISEASE;
D O I
10.5664/jcsm.6126
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: Nocturnal gastroesophageal reflux (nGER) is common among patients with obstructive sleep apnea (OSA). Previous studies demonstrated that continuous positive airway pressure (CPAP) reduces symptoms of nGER. However, improvement in nGER symptoms based on objective CPAP compliance has not been documented. We have examined the polysomnographic characteristics of patients with nGER and OSA and looked for association of OSA severity and CPAP compliance with improvement in nGER symptoms. Methods: We interviewed 85 veterans with OSA to assess their daytime sleepiness (Epworth Sleepiness scale [ESS]) and nGER symptom frequency after their polysomnography and polysomnographic data were reviewed. At 6 months' follow-up, ESS score, nGER score, and CPAP machine compliance data were reassessed. Data from 6 subjects were dropped from final analysis due to their initiation of new medication for nGER symptom since the initial evaluation. Results: Sixty-two of 79 (78%) patients complained of nGER symptoms during initial visit. At baseline, nGER score was correlated with sleep efficiency (r = 0.43), and BMI correlated with the severity of OSA (r = 0.41). ESS and nGER improved (p < 0.0001) in all patients after 6 months, but more significantly in CPAP compliant patients. A minimum CPAP compliance of 25% was needed to achieve any benefit in nGER improvement. Conclusions: Nocturnal gastroesophageal reflux is common among patients with OSA which increases sleep disruption and worsens the symptoms of daytime sleepiness. CPAP therapy may help improve the symptoms of both nocturnal acid reflux and daytime sleepiness, but adherence to CPAP is crucial to achieve this benefit.
引用
收藏
页码:1257 / 1261
页数:5
相关论文
共 50 条
  • [41] GASTROESOPHAGEAL REFLUX AND OBSTRUCTIVE SLEEP-APNEA
    SAMELSON, CF
    SLEEP, 1989, 12 (05) : 475 - 476
  • [42] Symptoms of laryngopharyngeal reflux in patients with obstructive sleep apnea
    Mjid, Meriem
    Bey, Rihab
    Toujani, Sonia
    Ouahchi, Yassine
    Sebii, Asma
    Ben Salah, Nozha
    Ben Hmida, Abdelmajid
    Louzir, Bechir
    Mhiri, Nadia
    Cherif, Jouda
    Beji, Majed
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [43] Survival benefit of CPAP therapy among dialysis patients with obstructive sleep apnea
    Iseki, Kunitoshi
    Moromizato, Takuhiro
    Iseki, Chiho
    Nakamura, Kei
    Nakamura, Hiroshi
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2024, : 485 - 491
  • [44] Nocturnal gastroesophageal reflux - Symptom of obstructive sleep apnea syndrome in association with impaired swallowing
    Janson, C
    Gislason, T
    CHEST, 2002, 122 (06) : 2267 - 2267
  • [45] TREATMENT OF EXTRAESOPHAGEAL REFLUX WITH NASAL CPAP IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
    Arunthari, V
    Waller, E. A.
    Fredrickson, P. A.
    Lin, S.
    Castillo, P.
    DeVault, K. R.
    Heckman, M. G.
    Diehl, N. N.
    Lee, A. S.
    Kaplan, J.
    SLEEP, 2010, 33 : A151 - A151
  • [46] Adherence to CPAP therapy improves quality of life and reduces symptoms among obstructive sleep apnea syndrome patients
    Eirini Avlonitou
    Fotis Kapsimalis
    George Varouchakis
    Constantine I. Vardavas
    Panagiotis Behrakis
    Sleep and Breathing, 2012, 16 : 563 - 569
  • [47] Adherence to CPAP therapy improves quality of life and reduces symptoms among obstructive sleep apnea syndrome patients
    Avlonitou, Eirini
    Kapsimalis, Fotis
    Varouchakis, George
    Vardavas, Constantine I.
    Behrakis, Panagiotis
    SLEEP AND BREATHING, 2012, 16 (02) : 563 - 569
  • [48] Gastroesophageal reflux and obstructive sleep apnea: Can reflux alter obstructive sleep apnea and sleep patterns in mild OSA?
    Orr, W. C.
    Robert, J. J.
    Houck, J. R.
    Giddens, C. L.
    SLEEP, 2006, 29 : A318 - A318
  • [49] The effect of CPAP therapy on heart rate variability in patients with obstructive sleep apnea
    Magda Grzęda-Hałon
    Małgorzata Poręba
    Gabriela Gut
    Karolina Czerwińska
    Paweł Gać
    Helena Martynowicz
    Grzegorz Mazur
    Rafał Poręba
    Sleep and Biological Rhythms, 2023, 21 : 143 - 154
  • [50] Effect of CPAP therapy on daytime cardiovascular regulations in patients with obstructive sleep apnea
    Penzel, T.
    Riedl, M.
    Gapelyuk, A.
    Suhrbier, A.
    Bretthauer, G.
    Malberg, H.
    Schoebel, C.
    Fietze, I.
    Heitmann, J.
    Kurths, J.
    Wessel, N.
    COMPUTERS IN BIOLOGY AND MEDICINE, 2012, 42 (03) : 328 - 334