Nanomaterial-Based Treatments for Medical Device-Associated Infections

被引：49

作者：

Nhiem Tran ^{[1
,2
]}

Tran, Phong A. ^{[3
]}

机构：

[1] Brown Univ, Dept Orthopaed, Rhode Isl Hosp, Providence, RI 02903 USA

[2] Brown Univ, Alpert Med Sch, Providence, RI 02903 USA

[3] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

来源：

CHEMPHYSCHEM | 2012年 / 13卷 / 10期

关键词：

biofilm; biotechnology; infection; nanoparticles; nanotechnology; ZERO-VALENT IRON; FULLERENE WATER SUSPENSION; WALLED CARBON NANOTUBES; INGUINAL-HERNIA REPAIR; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITY; OXIDE NANOPARTICLES; SILVER NANOPARTICLES; ZNO NANOPARTICLES; BACTERICIDAL ACTIVITY;

D O I：

10.1002/cphc.201200091

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Bacterial infections remain one of the biggest concerns to our society. Conventional antibiotic treatments showed little effect on the increasing number of antibiotic-resistant bacteria. Advances in synthetic chemistry and nanotechnology have resulted in a new class of nanometer-scale materials with distinguished properties and great potential to be an alternative for antibiotics. In this Minireview, we address the current situation of medical-device-associated infections and the emerging opportunities for antibacterial nanomaterials in preventing these complications. Several important antimicrobial nanomaterials emergent from advances in synthesis chemistry are introduced and their bactericidal mechanisms are analyzed. In addition, concerns regarding the biocompatibility of such materials are also addressed.

引用

页码：2481 / 2494

页数：14

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