Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

被引：33
|
作者：
Sala-Rabanal, Monica [1 ,2 ]
Yurtsever, Zeynep [2 ,3 ,4 ,5 ]
Berry, Kayla N. [4 ,6 ]
Brett, Tom J. [1 ,2 ,4 ,5 ,7 ]
机构：
[1] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Ctr Invest Membrane Excitabil Dis, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Biochem Program, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Drug Discovery Program Pulm & Crit Care Med, St Louis, MO 63110 USA
[6] Washington Univ, Sch Med, Med Sci Training Program, St Louis, MO 63110 USA
[7] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
关键词：
BORDETELLA-PERTUSSIS INFECTION; BRONCHIAL EPITHELIAL-CELLS; ANION TRANSPORTER PENDRIN; SLC26 GENE FAMILY; MUCUS PRODUCTION; HUMAN CLCA1; FUNCTIONAL-ANALYSIS; MUCIN SECRETION; MOUSE MODELS; STAS DOMAIN;
D O I：
10.1155/2015/497387
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
引用
收藏
页数：13
相关论文
共 50 条
  • [21] Targeting Cytokines as Evolving Treatment Strategies in Chronic Inflammatory Airway Diseases
    Garth, Jaleesa
    Barnes, Jarrod W.
    Krick, Stefanie
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (11)
  • [22] Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels?
    Charity Duran
    H Criss Hartzell
    Acta Pharmacologica Sinica, 2011, 32 : 685 - 692
  • [23] Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels?
    Duran, Charity
    Hartzell, H. Criss
    ACTA PHARMACOLOGICA SINICA, 2011, 32 (06) : 685 - 692
  • [24] Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases
    Elzein, Elfatih
    Kalla, Rao V.
    Li, Xiaofen
    Perry, Thao
    Gimbel, Art
    Zeng, Dewan
    Lustig, David
    Leung, Kwan
    Zablocki, Jeff
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (07) : 2267 - 2278
  • [25] Plasmalogens and platelet-activating factor roles in chronic inflammatory diseases
    Tremblay, Marie-Eve
    Almsherqi, Zakaria A.
    Deng, Yuru
    BIOFACTORS, 2022, 48 (06) : 1203 - 1216
  • [26] The link between ferroptosis and airway inflammatory diseases: A novel target for treatment
    Lin, Zhiwei
    Yang, Xiaojing
    Guan, Lili
    Qin, Lijie
    Ding, Jiabin
    Zhou, Luqian
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 9
  • [27] Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label
    de Vries, Rianne
    Dagelet, Yennece W. F.
    Spoor, Pien
    Snoey, Erik
    Jak, Patrick M. C.
    Brinkman, Paul
    Dijkers, Erica
    Bootsma, Simon K.
    Elskamp, Fred
    de Jongh, Frans H. C.
    Haarman, Eric G.
    in't Veen, Johannes C. C. M.
    Maitland-van der Zee, Anke-Hilse
    Sterk, Peter J.
    EUROPEAN RESPIRATORY JOURNAL, 2018, 51 (01)
  • [28] Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions
    Wei-jie Guan
    Yang Peng
    Xiao-xue Zi
    Kai Sen Tan
    Ting-ting He
    Nan-shan Zhong
    De Yun Wang
    Current Allergy and Asthma Reports, 2018, 18
  • [29] Inflammatory Phenotyping Of Chronic Airway Diseases (including Both Asthma And COPD) By Breathomics
    De Vries, R.
    Dagelet, J. W. F.
    Brinkman, P.
    Dijkers, E.
    De Jongh, F. H. C.
    Sterk, P. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
  • [30] Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases
    Giudetti, Anna Maria
    Cagnazzo, Raffaele
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2012, 99 (3-4) : 57 - 67
12345