MiRNAs Predict the Prognosis of Patients with Triple Negative Breast Cancer: A Meta-Analysis

被引:16
|
作者
Liu, Yanli [1 ]
Zhang, Yuchao [2 ]
Li, Qingfu [3 ]
Li, Junfang [2 ]
Ma, Xiaotian [2 ]
Xing, Jinfang [2 ]
Rong, Shouhua [2 ]
Wu, Zhong [4 ]
Tian, Yuan [2 ]
Li, Jing [2 ]
Jia, Liting [2 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 3, Dept Reprod Ctr, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 3, Dept Clin Lab, Zhengzhou, Peoples R China
[3] Peoples Hosp Henan Prov, Dept Stomatol, Zhengzhou, Peoples R China
[4] Henan Univ, Women & Infants Hosp Zhengzhou, Dept Clin Lab, Zhengzhou, Peoples R China
来源
PLOS ONE | 2017年 / 12卷 / 01期
关键词
SUPPRESSES TUMOR PROLIFERATION; HIGH EXPRESSION; POOR-PROGNOSIS; CIRCULATING MICRORNAS; SURVIVAL; BIOMARKERS; SIGNATURE; PATTERNS; MIR-21;
D O I
10.1371/journal.pone.0170088
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose miRNAs are stable and can be extracted from tissues, blood and other body fluid without degradation. miRNAs are abnormally expressed in the presence of a pathological status, including cancer. Therefore, miRNAs are ideal biomarkers for cancer diagnosis and prognosis. Patients with triple negative breast cancer (TNBC) suffer the worst prognosis, although great efforts have been made. Many studies have investigated the role of miRNAs in predicting the outcomes of TNBC patients for better adjustment of treatment. However, results were inconsistent. Thus, we performed a meta-analysis to summarize the published studies for conclusive results. Methods Eligible studies from different database were retrieved from the online databases, and we used STSTA 12.0 to analysis the prognostic role of miRNAs in triple negative breast cancer. Results Overall high miRNA expression indicated a worse survival with HR value of 1.78 (95% CI: 0.97-3.25). However, subtotal HRs of oncogenic miRNAs and tumor suppressive miRNAs were 2.73 (95% CI: 2.08-3.57; P<0.001) and 0.44 (95% CI: 0.21-0.90; P = 0.024), respectively, and no heterogeneity was observed within the subgroups. Conclusions The miRNAs showed a slightly stronger prognostic value for disease-free survival, relapse-free survival and distant metastasis-free survival compared to the overall survival of TNBC patients. Circulating miRNAs could serve as potential biomarkers for the prognosis of TNBC patients and need further investigation.
引用
收藏
页数:13
相关论文
共 50 条
  • [11] Effect of neoadjuvant chemotherapy in patients with triple-negative breast cancer: A meta-analysis
    Tian, Muyou
    Zhong, Yahua
    Zhou, Fuxiang
    Xie, Conghua
    Zhou, Yunfeng
    Liao, Zhengkai
    ONCOLOGY LETTERS, 2015, 9 (06) : 2825 - 2832
  • [12] Atezolizumab and pembrolizumab in triple-negative breast cancer: a meta-analysis
    Latif, Farah
    Jabbar, Hira Bint Abdul
    Malik, Hamna
    Sadaf, Humaira
    Sarfraz, Azza
    Sarfraz, Zouina
    Cherrez-Ojeda, Ivan
    EXPERT REVIEW OF ANTICANCER THERAPY, 2022, 22 (02) : 229 - 235
  • [13] ANALYSIS AND PROGNOSIS OF TRIPLE NEGATIVE "BASALLIKE" BREAST CANCER
    Marinopoulos, S.
    Dimitrakakis, C.
    Sotiropoulou, M.
    Antsaklis, A.
    ANNALS OF ONCOLOGY, 2010, 21 : 32 - 32
  • [14] Understanding the association between excess body weight and prognosis in triple-negative breast cancer: A meta-analysis
    Goncalves, Larissa Vaz
    Protani, Melinda M.
    Saunus, Jodi M.
    Colditz, Graham A.
    Reeves, Marina M.
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2022, 18 : 70 - 70
  • [15] Diagnostic value of ultrasound elastography in triple negative breast cancer: A meta-analysis
    Wang, Fei
    Wang, Hongjiang
    MEDICINE, 2023, 102 (06)
  • [16] From transcriptome meta-analysis to targeted therapies in triple negative breast cancer
    Rozali, E.
    Al-Ejeh, F.
    CANCER RESEARCH, 2016, 76
  • [17] Efficacy and Safety of Capecitabine for Triple-Negative Breast Cancer: A Meta-Analysis
    Xun, Xueqiong
    Cao, Qinguang
    Hong, Pan
    Rai, Saroj
    Zhou, Yeming
    Liu, Ruikang
    Hu, Huiyong
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [18] Prognostic value of androgen receptor in triple negative breast cancer: A meta-analysis
    Wang, Changjun
    Pan, Bo
    Zhu, Hanjiang
    Zhou, Yidong
    Mao, Feng
    Lin, Yan
    Xu, Qianqian
    Sun, Qiang
    ONCOTARGET, 2016, 7 (29) : 46482 - 46491
  • [19] Meta-Analysis of Prevalence of Triple-Negative Breast Cancer and Its Clinical Features at Incidence in Indian Patients With Breast Cancer
    Kulkarni, Apurv
    Kelkar, Devaki A.
    Parikh, Nidhi
    Shashidhara, Lingadahalli S.
    Koppiker, Chaitanyanand B.
    Kulkarni, Madhura
    JCO GLOBAL ONCOLOGY, 2020, 6 : 1052 - 1062
  • [20] Continental differences in the association between excess body weight and prognosis in triple-negative breast cancer: a meta-analysis
    Vaz-Goncalves, Larissa
    Protani, Melinda M.
    Saunus, Jodi M.
    Colditz, Graham A.
    Reeves, Marina M.
    BREAST CANCER RESEARCH AND TREATMENT, 2025, 209 (02) : 215 - 227