MEK-inhibitor (inh) and hydroxychloroquine (HCQ) in KRAS-mutated advanced pancreatic ductal adenocarcinoma (PDAC).

被引:0
|
作者
Mehdi, Maahum
Thalji, Samih Z.
Shreenivas, Aditya V.
Chakrabarti, Sakti
Thomas, James P.
Christians, Kathleen K.
Evans, Douglas B.
Hall, William A.
Erickson, Beth
Thapa, Bicky
Ahmed, Gulrayz
Yazdanpanah, Omid
Kurzrock, Razelle
Aldakkak, Mohammed
Holden, Mary Beth
Ben George
Tsai, Susan
Oxencis, Carolyn
McFall, Thomas
Kamgar, Mandana
机构
[1] Med Coll Wisconsin, Wauwatosa, WI USA
[2] Med Coll Wisconsin, Milwaukee, WI USA
[3] Mayo Clin, Rochester, MN USA
[4] Cleveland Clin, Dept Med, Cleveland, OH USA
[5] Wayne State Univ, Detroit, MI USA
[6] Wisconsin Canc Ctr, Med Coll, Milwaukee, WI USA
[7] Med Coll Wisconsin, Dept Surg, Milwaukee, WI USA
[8] Med Coll Wisconsin, 8701W Watertown Plank Rd, Milwaukee, WI USA
[9] Froedtert & Med Coll Wisconsin, Milwaukee, WI USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e16260
引用
收藏
页码:E16260 / E16260
页数:1
相关论文
共 50 条
  • [11] Genomic characterization of ATM alterations in advanced pancreatic ductal adenocarcinoma (PDAC).
    Perera, Sheron
    Denroche, Robert Edward
    Holter, Spring
    Kelly, Deirdre
    Zhang, Amy
    Wang Yifan
    Dodd, Anna
    Ramotar, Stephanie
    Hutchinson, Shawn
    Tehfe, Mustapha
    Ramjeesingh, Ravi
    Biagi, James Joseph
    Wilson, Julie
    Notta, Faiyaz
    Fischer, Sandra
    Zogopoulos, George
    Grant, Robert C.
    Gallinger, Steven
    Knox, Jennifer J.
    O'Kane, Grainne M.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [12] MEKiAUTO: A phase I/II open-label study of combination therapy with the MEK inhibitor cobimetinib, Immune-checkpoint blockade with atezolizumab, and the AUTOphagy inhibitor hydroxychloroquine in KRAS-mutated advanced malignancies.
    Raufi, Alexander
    Wong, Winston
    Lee, Shing Mirn
    Manji, Gulam Abbas
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [13] Skeletal metastases in advanced pancreatic ductal adenocarcinoma (PDAC): A retrospective analysis.
    Puri, Akshjot
    Chang, John
    Dragovich, Tomislav
    Lucente, Patricia
    Kundranda, Madappa N.
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04)
  • [14] RANKL acts an unfavorable prognostic biomarker and potential target in advanced KRAS-mutated lung adenocarcinoma
    Li, Hong-Shuai
    Liu, Cheng-Ming
    Wang, Yan
    THORACIC CANCER, 2023, 14 (15) : 1368 - 1382
  • [15] Molecular profiling of advanced pancreatic ductal adenocarcinoma (PDAC): Role of ctDNA.
    Lamarca, Angela
    McNamara, Mairead Geraldine
    Hubner, Richard
    Valle, Juan W.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [16] Prognostic value of KRAS and PI3K pathway mutations for advanced pancreatic ductal adenocarcinoma (PDAC) patients (pts).
    Diehl, Adam
    Hannan, Lindsay Marie
    Chiorean, Elena Gabriela
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [17] Impact of EMT status on the efficacy of the combination of RAF/MEK clamp with FAK inhibitor in KRAS-mutated lung cancer
    Yoshimura, Akihiro
    Horinaka, Mano
    Yaoi, Takeshi
    Ono, Hisako
    Itoh, Kyoko
    Yamada, Tadaaki
    Takayama, Koichi
    Sakai, Toshiyuki
    CANCER SCIENCE, 2025, 116 : 1294 - 1294
  • [18] THE EVALUATION OF SELUMETINIB A MEK-INHIBITOR WITH AND WITHOUT THE ADDITION OF ERLOTINIB IN KRAS MUTATED NON-SMALL CELL LUNG CANCER
    Carter, C.
    Rajan, A.
    Khozin, S.
    Thomas, A.
    Lopez-Chavez, A.
    Brzezniak, C.
    Doyle, L.
    Keen, C.
    Manu, M.
    Raffeld, M.
    Giaccone, G.
    ANNALS OF ONCOLOGY, 2013, 24 : 15 - 15
  • [19] Prognostic utility of preoperative and postoperative KRAS-mutated circulating tumor DNA (ctDNA) in resected pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
    Alqahtani, Ali
    Alloghbi, Abdurahman
    Coffin, Philip
    Yin, Chao
    Mukherji, Reetu
    Weinberg, Benjamin A.
    SURGICAL ONCOLOGY-OXFORD, 2023, 51
  • [20] Comprehensive genomic profiling (CGP) in KRAS wild-type (WT) pancreatic ductal adenocarcinoma (PDAC).
    George, Ben
    Greenbowe, Joel R.
    Hendifar, Andrew Eugene
    Golan, Talia
    Javle, Milind M.
    Maitra, Anirban
    Bahary, Nathan
    Schrock, Alexa Betzig
    Stephens, Philip J.
    Miller, Vincent A.
    Ross, Jeffrey S.
    Yakirevich, Evgeny
    Ritch, Paul S.
    Thomas, James P.
    Ali, Siraj Mahamed
    Singhi, Aatur D.
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04)