Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies

被引：134

作者：

Andreotti, F ^{[1
]}

Porto, I ^{[1
]}

Crea, F ^{[1
]}

Maseri, A ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy

来源：

HEART | 2002年 / 87卷 / 02期

关键词：

D O I：

10.1136/heart.87.2.107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation and genetics are both prominent mechanisms in the pathogenesis of atherosclerosis and arterial thrombosis. Accordingly, a number of population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules tumour necrosis factors (TNF) alpha. and beta, transforming growth factors (TGF) beta1 and 2, interleukin (IL) 1 and its receptor antagonist (IL 1 ra), CID 14 (the receptor for lipopolysaccharide), P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Although they are very preliminary and partly conflicting, the data provide some evidence that alterations in the genetics of the inflammatory system may modify the risk of ischaemic heart disease.

引用

页码：107 / 112

页数：6

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