Cell pairing using a dielectrophoresis-based device with interdigitated array electrodes

被引：62

作者：

Sen, Mustafa ^{[1
]}

Ino, Kosuke ^{[1
]}

Ramon-Azcon, Javier ^{[2
]}

Shiku, Hitoshi ^{[1
]}

Matsue, Tomokazu ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Environm Studies, Sendai, Miyagi 9808579, Japan

[2] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808579, Japan

来源：

LAB ON A CHIP | 2013年 / 13卷 / 18期

基金：

日本学术振兴会;

关键词：

NEGATIVE DIELECTROPHORESIS; SURFACE-ANTIGENS; LIVING CELLS; CHIP DEVICE; MICROARRAY; MICROWELLS; SEPARATION; CULTURE;

D O I：

10.1039/c3lc50561h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a chip device with an array of 900 gourd-shaped microwells designed to pair single cells of different types. The device consists of interdigitated array (IDA) electrodes and uses positive dielectrophoresis to trap cells within the microwells. Each side of a microwell is on a different comb of the IDA, so that cells of different types are trapped on opposite sides of the microwells, leading to close cell pairing. Using this device, a large number of cell pairs can be formed easily and rapidly, making it a highly attractive tool for controllable cell pairing in a range of biological applications.

引用

页码：3650 / 3652

页数：3

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