Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin

被引：0

作者：

Shao, Pingxuan ^{[1
]}

Lu, Wei ^{[1
]}

Wang, Lei ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China

来源：

CURRENT ORGANIC SYNTHESIS | 2020年 / 17卷 / 07期

基金：

中国博士后科学基金;

关键词：

Natural product; alkaloid; camptothecin; CDE ring; total syntheses; protecting group-free; PLANT ANTITUMOR AGENTS; FORMAL TOTAL-SYNTHESIS; CASCADE CYCLIZATION SYNTHESIS; (20S)-CAMPTOTHECIN; (+/-)-CAMPTOTHECIN; IRINOTECAN; DRUGS;

D O I：

10.2174/1570179417666200611125740

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be helpful for the future development of industry-scale syntheses of camptothecin-family alkaloids.

引用

页码：588 / 591

页数：4

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