Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin

被引：0
|
作者：
Shao, Pingxuan [1 ]
Lu, Wei [1 ]
Wang, Lei [1 ]
机构：
[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China
来源：
CURRENT ORGANIC SYNTHESIS | 2020年 / 17卷 / 07期
基金：
中国博士后科学基金;
关键词：
Natural product; alkaloid; camptothecin; CDE ring; total syntheses; protecting group-free; PLANT ANTITUMOR AGENTS; FORMAL TOTAL-SYNTHESIS; CASCADE CYCLIZATION SYNTHESIS; (20S)-CAMPTOTHECIN; (+/-)-CAMPTOTHECIN; IRINOTECAN; DRUGS;
D O I：
10.2174/1570179417666200611125740
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be helpful for the future development of industry-scale syntheses of camptothecin-family alkaloids.
引用
收藏
页码：588 / 591
页数：4
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