Enantioselective conjugate addition of diethylzinc to cyclic enones with chiral aryl diphosphite-copper catalysts

被引：79
|
作者：
Yan, M
Chan, ASC [1 ]
机构：
[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 36期
关键词：
D O I：
10.1016/S0040-4039(99)01272-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of C-2-symmetric aryl diphosphites based on chiral binaphthol were prepared and their copper complexes were found to be efficient catalysts for the conjugate addition of diethylzinc to cyclic enones. Good enantioselectivities (up to 89.8 and 88.7% ee, respectively) were obtained in the conjugate addition of diethylzinc to 2-cyclohexenone and 2-cyclopentenone. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6645 / 6648
页数：4
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