LIPID RAFTS ACCUMULATE MUTANT HUNTINGTIN AND REVEAL CHANGES IN AKT PATHWAY IN HUNTINGTON's DISEASE MICE: ROLE IN NEURODEGENERATION

被引:0
|
作者
Valencia, A. [1 ,2 ]
Reeves, P. B. [1 ,2 ]
Sapp, E. [1 ,2 ]
Li, X. [1 ,2 ]
Alexander, J. [1 ,2 ]
Kegel, K. B. [1 ,2 ]
Chase, K. [3 ]
Aronin, N. [3 ]
DiFiglia, M. [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Charlestown, MA USA
[2] Harvard Univ, Sch Med, Charlestown, MA USA
[3] Univ Massachusetts, Sch Med, Worcester, MA USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:43 / 43
页数:1
相关论文
共 39 条
  • [31] Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice
    Chuan-En Wang
    Shihua Li
    Xiao-Jiang Li
    Molecular Brain, 3
  • [32] Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice
    Wang, Chuan-En
    Li, Shihua
    Li, Xiao-Jiang
    MOLECULAR BRAIN, 2010, 3
  • [33] A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration
    Lu, Boxun
    Palacino, James
    FASEB JOURNAL, 2013, 27 (05): : 1820 - 1829
  • [34] Application of Therapeutic Artificial miRNAs in the CNS: Non-Allele-Specific Silencing of Mutant and Wildtype Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice
    Boudreau, Ryan L.
    McBride, Jodi L.
    Martins, Ines
    Shen, Shihao
    Xing, Yi
    Carter, Barrie J.
    Davidson, Beverly L.
    MOLECULAR THERAPY, 2009, 17 : S163 - S164
  • [35] Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington's Disease Knock-In Mice
    Kovalenko, Marina
    Dragileva, Ella
    St Claire, Jason
    Gillis, Tammy
    Guide, Jolene R.
    New, Jaclyn
    Dong, Hualing
    Kucherlapati, Raju
    Kucherlapati, Melanie H.
    Ehrlich, Michelle E.
    Lee, Jong-Min
    Wheeler, Vanessa C.
    PLOS ONE, 2012, 7 (09):
  • [36] Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington?s disease transgenic mice
    Farzana, Farheen
    McConville, Malcolm J.
    Renoir, Thibault
    Li, Shanshan
    Nie, Shuai
    Tran, Harvey
    Hannan, Anthony J.
    Hatters, Danny M.
    Boughton, Berin A.
    NEUROBIOLOGY OF DISEASE, 2023, 176
  • [37] Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington's Disease
    Jang, Minhee
    Lee, Seung Eun
    Cho, Ik-Hyun
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2018, 12
  • [38] Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway
    Liu, Shu-ying
    Yu, Xiao-lin
    Zhu, Jie
    Liu, Xiang-meng
    Zhang, Yue
    Dong, Quan-xiu
    Ma, Shan
    Liu, Rui-tian
    BRAIN RESEARCH, 2018, 1697 : 21 - 33
  • [39] AAV2:2.retro-Mediated Delivery of Mutant Huntingtin throughout Cortico-Basal Ganglia Circuitry Leads to the Progressive Development of Motor and Cognitive Decline, along with Microstructural Changes in White and Gray Matter, in a Novel Rhesus Macaque Model of Huntington's Disease
    Weiss, Alison R.
    Liguore, William A.
    Brandon, Kristin
    Wang, Xiaojie
    Liu, Zheng
    Domire, Jackie
    Button, Dana
    Kroenke, Christopher D.
    McBride, Jodi L.
    MOLECULAR THERAPY, 2021, 29 (04) : 33 - 34