Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behcet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural sinus thrombosis (10), ischemic stroke (5) or headache (13) were measured by ELISA. Samples from multiple sclerosis, subacute sclerosing panencephalitis, and noninflammatory neurological disorders were used as controls. CSF but not serum samples of neuro-BD patients with acute pNB displayed significantly increased IL-6 levels as compared to other groups. Chronic progressive pNB patients also showed increased CSF IL-6 levels, albeit less prominent. Patients with increased CSF IL-6 levels were more likely to have increased CSF cell counts and total protein levels and these three parameters were correlated with long-term (>= 3 years) disease outcome. In four chronic progressive patients. IL-6 was elevated despite otherwise normal CSF. CSF IL-6 seems to be a marker of disease activity and long-term outcome for pNB along with CSF cell count and protein levels. CSF IL-6 could be used in chronic progressive patients who have normal CSF cell, or protein levels to detect disease activity. (C) 2008 Elsevier Ltd. All rights reserved.
机构:
Ankara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, TurkeyAnkara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, Turkey
Sorgun, Mine Hayriye
Kuzu, Muge
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Ankara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, TurkeyAnkara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, Turkey
Kuzu, Muge
Erdogan, Seyda
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Ankara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, TurkeyAnkara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, Turkey
Erdogan, Seyda
Yucesan, Canan
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Ankara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, TurkeyAnkara Univ, Dept Neurol, Sch Med, Ibni Sina Hosp, TR-06230 Ankara, Turkey
机构:
Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Shugaiv, Erkingul
Kiyat-Atamer, Asli
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Istanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Kiyat-Atamer, Asli
Tuzun, Erdem
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Istanbul Univ, Inst Expt Med & Res, Dept Neurosci, TR-34093 Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Tuzun, Erdem
Kurtuncu, Murat
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Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Kurtuncu, Murat
Baral-Kulaksizoglu, Isin
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Istanbul Univ, Istanbul Fac Med, Dept Psychiat, TR-34093 Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Baral-Kulaksizoglu, Isin
Demir, Gulsen Akman
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Istanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, TurkeyIstanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey
机构:
Yonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South KoreaYonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South Korea
Lee, SH
Yoon, PH
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Yonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South KoreaYonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South Korea
Yoon, PH
Park, SJ
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Yonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South KoreaYonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South Korea
Park, SJ
Kim, DI
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Yonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South KoreaYonsei Univ, Dept Diagnost Radiol, Res Inst Radiol Sci, Coll Med,Seodaemun Ku, Seoul 120752, South Korea