Effect of diet-induced weight loss on inflammatory cytokines in obese women

被引:33
|
作者
Tajik, N. [1 ,2 ]
Keshavarz, S. A. [1 ]
Masoudkabir, F. [3 ]
Djalali, M. [1 ]
Sadrzadeh-Yeganeh, H. Hale [1 ]
Eshraghian, M. R. [4 ]
Chamary, M. [1 ]
Ahmadivand, Z. [1 ]
Yazdani, T. [2 ]
Javanbakht, M. H. [1 ]
机构
[1] Univ Tehran Med Sci, Sch Publ Hlth, Dept Nutr & Biochem, Tehran 141556446, Iran
[2] Univ Tehran Med Sci, Endocrine & Metab Sci Res Inst, Obes & Food Grp Set, Tehran 141556446, Iran
[3] Univ Tehran Med Sci, SSRC, Tehran 141556446, Iran
[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran 141556446, Iran
关键词
Adipocytokines; inflammation; metabolic syndrome; obesity; weight reduction; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; ADIPOSE-TISSUE; MYOCARDIAL-INFARCTION; INTERLEUKIN-10; LEVELS; PLASMA-LEVELS; RISK-FACTORS; ASSOCIATION;
D O I
10.3275/8465
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Obesity is associated with low-grade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obese patients. Aim: To evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss. Subjects and methods: Twenty-nine pre-menopausal obese women (body mass index >= 30 kg/m(2)) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obese women, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obese women restricted their caloric intake (by 500-1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks. Results: By completing the dietary intervention program, weight (Delta=-10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10. Conclusion: Our study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obese women. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease. (C)2013, Editrice Kurtis
引用
收藏
页码:211 / 215
页数:5
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