Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone

被引：16
|
作者：
Wong, Chek-Ming [1 ]
Loh, Teck-Peng [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 639716, Singapore
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 26期
关键词：
tedanolide; stereoselective; aldol; boron reagent; fragment assembly; 18-MEMBERED ANTITUMOR MACROLIDE; ALDOL ALDOL PROCESS; STEREOSELECTIVE-SYNTHESIS; CHIRAL ETHYLKETONES; EFFICIENT SYNTHESIS; C1-C-11; FRAGMENT; KETONES; CONVERSION; METHYL; CONDENSATIONS;
D O I：
10.1016/j.tetlet.2006.04.044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4485 / 4489
页数：5
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