Synthesis, structures and biological activity of some 4-amino-3-cinnoline-carboxylic acid derivatives .2.

被引：0
|
作者：
Stanczak, A [1 ]
Lewgowd, W [1 ]
Ochocki, Z [1 ]
Pakulska, W [1 ]
Szadowska, A [1 ]
机构：
[1] MED UNIV LODZ, DEPT PHARMACODYNAM, PL-90151 LODZ, POLAND
来源：
PHARMAZIE | 1997年 / 52卷 / 02期
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D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with amines to the corresponding 4-amino-3-cinnolinecarboxamides 7,8. A variety of pharmacological tests showed a significant CNS activity of some new amides. Decarboxylation of 4-amino-3-cinnolinecarboxylic acids 1 yielded the corresponding 4-aminocinnolines 4 and alkaline hydrolysis of 1 gave 4-oxo-3-cinnolinecarboxylic acids 2. The acids 1 were converted into pyrimido[5,4-c]cinnolines 6 on two ways of synthesis.
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页码：91 / 97
页数：7
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