Development of a CD123xCD3 bispecific antibody to treat acute myeloid leukemia (AML)

被引:0
|
作者
Gaudet, Francois
Nemeth, Jennifer F.
McDaid, Ronan
Li, Yingzhe
Harman, Benjamin
Millar, Hillary
Teplyakov, Alexey
Wheeler, John
Luo, Jinquan
Tam, Susan
Wu, Sheng-Jiun
Chen, Emily
Babich, Alexander
Elsayed, Yusri
Attar, Ricardo
机构
关键词
D O I
10.1158/1538-7445.AM2016-1492
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1492
引用
收藏
页数:3
相关论文
共 50 条
  • [21] Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia
    Hutmacher, Cornelia
    Volta, Laura
    Rinaldi, Francesco
    Murer, Patrizia
    Myburgh, Renier
    Manz, Markus G.
    Neri, Dario
    LEUKEMIA RESEARCH, 2019, 84
  • [22] CD123-CODV-TCE bispecific T-cell engager for acute myeloid leukemia (AML): Activity on primary AML and safety in non-human primates
    Bonnevaux, Helene
    Courta, Jacqueline
    Passe-Coutrin, Wilfried
    Bauchet, Anne-Laure
    Roobrouck, Annelies
    Amara, Celine
    Beys, Eric
    Balzano, Marielle
    Moulard, Maxime
    Meloni, Marco
    Dullaers, Melissa
    Chiron, Marielle
    Virone-Oddos, Angela
    CANCER RESEARCH, 2022, 82 (12)
  • [23] Tolerability and Single Agent Anti-Neoplastic Activity of the CD3xCD123 Bispecific Antibody APVO436 in Patients with Relapsed/Refractory AML or MDS
    Watts, Justin M.
    Lin, Tara L.
    Mims, Alice S.
    Patel, Prapti
    Shami, Paul J.
    Cull, Elizabeth H.
    Cogle, Christopher R.
    Lee, Cynthia
    Uckun, Fatih
    BLOOD, 2021, 138
  • [24] A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia
    Nair-Gupta, Priyanka
    Diem, Michael
    Reeves, Dara
    Wang, Weirong
    Schulingkamp, Robert
    Sproesser, Katrin
    Mattson, Bethany
    Heidrich, Bradley
    Mendonca, Mark
    Joseph, Jocelin
    Sendecki, Jocelyn
    Foulk, Brad
    Chu, Gerald
    Fink, Damien
    Jiao, Qun
    Wu, Sheng-Jiun
    Packman, Kathryn
    Elsayed, Yusri
    Attar, Ricardo
    Gaudet, Francois
    BLOOD ADVANCES, 2020, 4 (05) : 906 - 919
  • [25] Risk, Characteristics and Biomarkers of Cytokine Release Syndrome in Patients with Relapsed/Refractory AML or MDS Treated with CD3xCD123 Bispecific Antibody APVO436
    Uckun, Fatih M.
    Watts, Justin
    Mims, Alice S.
    Patel, Prapti
    Wang, Eunice
    Shami, Paul J.
    Cull, Elizabeth
    Lee, Cynthia
    Cogle, Christopher R.
    Lin, Tara L.
    CANCERS, 2021, 13 (21)
  • [26] A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia
    Djuretic, Ivana
    Krishnamoorthy, Veena
    Sommer, Cesar
    Dettling, Danielle E.
    Poulsen, Kris
    Chen, Wei
    Hu, Wenyue
    Chunyk, Allison Given
    Lindquist, Kevin
    Potluri, Shobha
    Rickert, Robert C.
    Sasu, Barbra
    Chaparro-Riggers, Javier
    Yeung, Yik Andy
    BLOOD, 2018, 132
  • [27] Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody
    Csoka, M
    Strauss, G
    Debatin, KM
    Moldenhauer, G
    LEUKEMIA, 1996, 10 (11) : 1765 - 1772
  • [28] Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia
    Han, Yoon-Chi
    Kahler, Jennifer
    Piche-Nicholas, Nicole
    Hu, Wenyue
    Thibault, Stephane
    Jiang, Fan
    Leal, Mauricio
    Katragadda, Madan
    Maderna, Andreas
    Dushin, Russell
    Prashad, Nadira
    Charati, Manoj B.
    Clark, Tracey
    Tumey, L. Nathan
    Tan, Xingzhi
    Giannakou, Andreas
    Rosfjord, Edward
    Gerber, Hans-Peter
    Tchistiakova, Lioudmila
    Loganzo, Frank
    O'Donnell, Christopher J.
    Sapra, Puja
    CLINICAL CANCER RESEARCH, 2021, 27 (02) : 622 - 631
  • [29] Risk and Severity of Cytokine Release Syndrome in Patients with Relapsed/Refractory (R/R) AML or MDS Treated with CD3xCD123 Bispecific Antibody APVO436
    Lim, Tara L.
    Watts, Justn M.
    Mims, Alice S.
    Patel, Prapti
    Shami, Paul J.
    Cull, Elizabeth H.
    Cogle, Christopher R.
    Lee, Cynthia
    Uckun, Faith
    BLOOD, 2021, 138
  • [30] A novel immunoliposome mediated by CD123 antibody targeting to acute myeloid leukemia cells
    Wang, Yin
    Liu, Furong
    Wang, Qiantao
    Xiang, Honglin
    Jin, Hui
    Li, Hui
    Mao, Shengjun
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 529 (1-2) : 531 - 542